Hydramine and Pentoxifylline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydramine (diphenhydramine hydrochloride) and Pentoxifylline (pentoxifylline). Common drug interactions include infusion site haemorrhage among females and gastrooesophageal reflux disease among males.

The phase IV clinical study analyzes what interactions people have when they take Hydramine and Pentoxifylline. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Pentoxifylline?

Pentoxifylline has active ingredients of pentoxifylline. eHealthMe is studying from 5,997 Pentoxifylline users. Check the latest studies of Pentoxifylline.

On Jul, 11, 2026

83 people who take Hydramine and Pentoxifylline together, and have interactions are studied.

Hydramine and Pentoxifylline drug interactions.

What are the common drug interactions of Hydramine and Pentoxifylline, by gender? *:

female:

Infusion site haemorrhage (bleeding from infusion site)
Quality of life decreased
Renal failure (kidney dysfunction)
Renal transplant
Infection
Drug ineffective
Infusion related reaction
Infusion site erythema (reddening of the skin at infusion site)
Infusion site swelling
Injection site extravasation (flow of (blood or lymph) from injection site)

male:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Skin ulcer
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Oesophageal dilatation (enlarged oesophagus)
Oral candidiasis (fungal infection of mouth)
Osteoporosis (bones weak and more likely to break)
Pneumonia
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Pulmonary function test decreased
Rales (an abnormal respiratory sound characterized by fine crackles)

What are the common drug interactions of Hydramine and Pentoxifylline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Decreased activity
Emotional distress
Fatigue (feeling of tiredness)
Pain
Quality of life decreased
Renal failure (kidney dysfunction)
Renal transplant

40-49:

Renal failure (kidney dysfunction)
Pain
Chronic kidney disease
Alanine aminotransferase increased
Aspartate aminotransferase increased
Herpes zoster
Palpitations (feelings or sensations that your heart is pounding or racing)
Rash
Weight increased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

50-59:

Abdominal pain
Chest pain
Disease progression
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Flatulence (flatus expelled through the anus)
Interstitial lung disease
Pain
Scleroderma (hard skin)
Total lung capacity decreased
Wheezing (a high-pitched whistling sound made while you breath)

60+:

Breast cancer stage i
Malaise (a feeling of general discomfort or uneasiness)
Infusion site haemorrhage (bleeding from infusion site)
Asthenia (weakness)
Infusion related reaction
Injection site extravasation (flow of (blood or lymph) from injection site)
Injection site reaction
Injection site thrombosis (injection site blood clotting)
Upper respiratory tract infection
Acute myocardial infarction (acute heart attack)

What are the existing conditions these people have? *

Interstitial Lung Disease: 17 people, 20.48%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 16 people, 19.28%
Immunodeficiency Common Variable: 12 people, 14.46%
Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 11 people, 13.25%
Pain: 7 people, 8.43%
Type 2 Diabetes: 5 people, 6.02%
Nausea (feeling of having an urge to vomit): 5 people, 6.02%
Multiple Myeloma (cancer of the plasma cells): 5 people, 6.02%
Infection: 5 people, 6.02%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 5 people, 6.02%

* Approximation only. Some reports may have incomplete information.

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