Hydrocodone and Fiorinal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocodone (hydrocodone bitartrate; ibuprofen) and Fiorinal (aspirin; butalbital; caffeine). Common drug interactions include asthma among females.

The phase IV clinical study analyzes what interactions people have when they take Hydrocodone and Fiorinal. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

On Jul, 11, 2026

15 people who take Hydrocodone and Fiorinal together, and have interactions are studied.

Hydrocodone and Fiorinal drug interactions.

What are the common drug interactions of Hydrocodone and Fiorinal, by gender? *:

female:

Asthma
Fall
Seasonal allergy (allergic condition due to certain season)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Spinal fracture (fracture in one of vertebrae)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Thyroid disorder (thyroid diseases)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest pain
Dizziness

male:

n/a

What are the common drug interactions of Hydrocodone and Fiorinal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Pneumonia
Tooth disorder (tooth disease)

50-59:

Asthma
Fall
Hypertension (high blood pressure)
Laceration (tearing of soft body tissue)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Chest pain
Dizziness
Drug hypersensitivity

60+:

Asthma
Cellulitis (infection under the skin)
Rhinorrhoea (watery mucus discharge from the nose)
Sneezing
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pruritus (severe itching at infusion site)
Infusion site urticaria (rash of round, red welts on the skin at infusion site)
Multiple allergies (allergy to multiple agents)
Seasonal allergy (allergic condition due to certain season)
Thyroid disorder (thyroid diseases)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 40.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 33.33%
Immunodeficiency Common Variable: 3 people, 20.00%
Sleep Disorder: 2 people, 13.33%
Headache (pain in head): 2 people, 13.33%
Bladder Disorder: 2 people, 13.33%
Cardiac Disorder: 2 people, 13.33%
Constipation: 2 people, 13.33%
Cough: 2 people, 13.33%
High Blood Pressure: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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