Hydrocodone and Skelaxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocodone (hydrocodone bitartrate; ibuprofen) and Skelaxin (metaxalone). Common drug interactions include intervertebral disc disorder among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocodone and Skelaxin. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

What is Skelaxin?

Skelaxin has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 9,706 Skelaxin users. Check the latest studies of Skelaxin.

On Jul, 08, 2026

64 people who take Hydrocodone and Skelaxin together, and have interactions are studied.

Hydrocodone and Skelaxin drug interactions.

What are the common drug interactions of Hydrocodone and Skelaxin, by gender? *:

female:

Intervertebral disc disorder (spinal disc disorder)
Nephropathy (damage to or disease of a kidney)
Tremor (trembling or shaking movements in one or more parts of your body)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Abnormal behaviour
Aggression
Agitation (state of anxiety or nervous excitement)
Asthenia (weakness)
Atrioventricular block second degree (heart block second degree)
Blood magnesium decreased

male:

Drug ineffective
Completed suicide (act of taking one's own life)
Neck pain
Atrophy (wasting away of a part of the body)
Mass
Spinal cord injury cervical (spinal cord injury at cervical vertebrae region)
Spinal osteoarthritis (joint cartilage loss in spine)
Intervertebral disc space narrowing (spinal disc space narrowing)
Spinal cord disorder (disease of spinal cord)
Alcohol use

What are the common drug interactions of Hydrocodone and Skelaxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Completed suicide (act of taking one's own life)
Drug ineffective
Drug toxicity
Pain
Pulmonary congestion (congestion in the lungs)
Depression
Intervertebral disc protrusion (spinal disc protrusion)
Pulmonary oedema (fluid accumulation in the lungs)
Abdominal pain
Activities of daily living impaired

40-49:

Chronic kidney disease
Agitation (state of anxiety or nervous excitement)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Anxiety
Anxiety disorder
Blood albumin decreased
Haematoma infection (infection with collection of blood outside the blood vessels)
Hepatic steatosis (fatty liver disease)
Injection site haemorrhage (bleeding from injection site)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)

50-59:

Intervertebral disc operation
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Neuralgia (pain in one or more nerves)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)
Renal failure chronic (long lasting kidney dysfunction)
Renal injury (kidney injury)

60+:

Chronic kidney disease
Fall
Anxiety
Cellulitis (infection under the skin)
Disease recurrence
Diverticulum intestinal haemorrhagic (a pouch that is attached to the first part of the small intestine with bleeding)
Femur fracture
Fracture delayed union (delayed cure of broken bone)
Fracture nonunion (permanent failure of healing following a broken bone)
Incision site complication

What are the existing conditions these people have? *

Pain: 22 people, 34.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 23.44%
Depression: 12 people, 18.75%
Infection: 12 people, 18.75%
High Blood Cholesterol: 11 people, 17.19%
Ill-Defined Disorder: 10 people, 15.62%
Muscle Spasms (muscle contraction): 10 people, 15.62%
Neuralgia (pain in one or more nerves): 8 people, 12.50%
Nausea (feeling of having an urge to vomit): 8 people, 12.50%
Cardiac Disorder: 8 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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