Hydrocortisone and Avalide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocortisone (hydrocortisone) and Avalide (hydrochlorothiazide; irbesartan). Common drug interactions include angina pectoris among females and pleurisy among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocortisone and Avalide. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocortisone?

Hydrocortisone has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 40,425 Hydrocortisone users. Check the latest studies of Hydrocortisone.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.



On Jul, 10, 2026

22 people who take Hydrocortisone and Avalide together, and have interactions are studied.

Hydrocortisone and Avalide drug interactions.

What are the common drug interactions of Hydrocortisone and Avalide, by gender? *:

female:

  1. Angina pectoris (chest pain due to ischemia of the heart muscle)
  2. Angioplasty
  3. Aortic valve stenosis (narrowing of the aortic valve)
  4. Diarrhoea
  5. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  6. Nausea (feeling of having an urge to vomit)
  7. Pain
  8. Syncope (loss of consciousness with an inability to maintain postural tone)
  9. Vomiting
  10. Abdominal pain

male:

  1. Pleurisy (inflammation of the pleurae, which causes pain when breathing)
  2. Ataxia (loss of full control of bodily movements)
  3. Vision blurred
  4. Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
  5. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  6. Drug ineffective
  7. Insomnia (sleeplessness)
  8. Insulin resistance
  9. Pulmonary embolism (blockage of the main artery of the lung)
  10. Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands)

What are the common drug interactions of Hydrocortisone and Avalide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Pain
  2. Syncope (loss of consciousness with an inability to maintain postural tone)
  3. Abdominal pain
  4. Anxiety
  5. Chest pain
  6. Multiple injuries
  7. Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
  8. Renal failure acute (rapid kidney dysfunction)
  9. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  10. Bradycardia (abnormally slow heart action)

60+:

  1. Pleurisy (inflammation of the pleurae, which causes pain when breathing)
  2. Abdominal pain
  3. Back pain
  4. Balance disorder
  5. Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)
  6. Breast mass
  7. Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
  8. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  9. Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
  10. Cardiac failure congestive

What are the existing conditions these people have? *

  1. Otitis (ear infection): 5 people, 22.73%
  2. Inflammation: 5 people, 22.73%
  3. Headache (pain in head): 4 people, 18.18%
  4. Ill-Defined Disorder: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrocortisone and Avalide?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Hydrocortisone and Avalide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydrocortisone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Avalide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Hydrocortisone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Avalide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on hydrocortisone and hydrochlorothiazide; irbesartan (the active ingredients of Hydrocortisone and Avalide, respectively), and Hydrocortisone and Avalide (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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