Hydrocortone and Simvastatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocortone (hydrocortisone acetate) and Simvastatin (simvastatin). Common drug interactions include malaise among females and insomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocortone and Simvastatin. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocortone?

Hydrocortone has active ingredients of hydrocortisone acetate. It is often used in pain. eHealthMe is studying from 912 Hydrocortone users. Check the latest studies of Hydrocortone.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

24 people who take Hydrocortone and Simvastatin together, and have interactions are studied.

Hydrocortone and Simvastatin drug interactions.

What are the common drug interactions of Hydrocortone and Simvastatin, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Multi-organ failure (multisystem organ failure)
Oedema (fluid collection in tissue)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia klebsiella (pneumonia caused by bacteria klebsiella)
Productive cough
Proteus infection (proteus can cause urinary tract infections)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Pyrexia (fever)

male:

Insomnia (sleeplessness)
Asthenia (weakness)
Bradycardia (abnormally slow heart action)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Injection site abscess
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

What are the common drug interactions of Hydrocortone and Simvastatin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Anaemia (lack of blood)
Blood erythropoietin decreased
Carnitine decreased
Device occlusion
Encephalitis herpes (inflammation of the brain due to herpes infection)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Insomnia (sleeplessness)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)

50-59:

Hypotension (abnormally low blood pressure)
Injection site abscess
Gallbladder disorder
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Pruritus (severe itching of the skin)
Purpura (purplish discoloration of the skin)
Sleep disorder
Vomiting

60+:

Dizziness
Vomiting
Cardiac failure acute
Cystitis (inflammation of the wall of the bladder)
Cytomegalovirus infection
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)
Haemodynamic instability (disturbances in the blood movement in our body)
Haemorrhage intracranial (bleeding within the skull)

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 25.00%
Acromegaly (body produces too much growth hormone, leading to excess growth of body tissues): 5 people, 20.83%
Lymphoma (cancer that begins in immune system cells): 3 people, 12.50%
Duodenitis (inflammation of the duodenum): 2 people, 8.33%
Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 2 people, 8.33%
Adverse Event: 2 people, 8.33%
Bacteraemia (presence of bacteria in the blood): 2 people, 8.33%
Bronchitis Chronic (inflammation of the mucous membrane in the bronchial tubes- chronic): 2 people, 8.33%
Depression: 2 people, 8.33%
Type 2 Diabetes: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrocortone and Simvastatin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously