Hydroxyzine and L-methylfolate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyzine (hydroxyzine hydrochloride) and L-methylfolate (folic acid). Common drug interactions include lethargy among females and streptococcal infection among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine and L-methylfolate. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,070 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is L-methylfolate?

L-methylfolate has active ingredients of folic acid. It is often used in depression. eHealthMe is studying from 619 L-methylfolate users. Check the latest studies of L-methylfolate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

16 people who take Hydroxyzine and L-methylfolate together, and have interactions are studied.

Hydroxyzine and L-methylfolate drug interactions.

What are the common drug interactions of Hydroxyzine and L-Methylfolate, by gender? *:

female:

Lethargy (tiredness)
Sedation
Speech disorder
Vertigo
Arthralgia (joint pain)
Asthenia (weakness)
Asthma
Blood pressure increased
Dizziness
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)

male:

Streptococcal infection
Anger
Ear infection

What are the common drug interactions of Hydroxyzine and L-Methylfolate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anger

20-29:

n/a

30-39:

n/a

40-49:

Infusion site pruritus (severe itching at infusion site)
Infusion site urticaria (rash of round, red welts on the skin at infusion site)

50-59:

n/a

60+:

Staphylococcal skin infection (skin infection by an infection with staphylococcus bacteria)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 37.50%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 3 people, 18.75%
Immunodeficiency Common Variable: 2 people, 12.50%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 12.50%
Migraine (headache): 2 people, 12.50%
Bipolar Disorder (mood disorder): 1 person, 6.25%
Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 1 person, 6.25%
Cystic Fibrosis (disease of the secretary glands): 1 person, 6.25%
Diarrhea: 1 person, 6.25%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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