Hydroxyzine and Wellbutrin sr drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyzine (hydroxyzine hydrochloride) and Wellbutrin sr (bupropion hydrochloride). Common drug interactions include loss of consciousness among females and somnolence among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine and Wellbutrin sr. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,070 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Wellbutrin sr?

Wellbutrin sr has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 13,112 Wellbutrin sr users. Check the latest studies of Wellbutrin sr.

On Aug, 07, 2026

92 people who take Hydroxyzine and Wellbutrin sr together, and have interactions are studied.

Hydroxyzine and Wellbutrin sr drug interactions.

What are the common drug interactions of Hydroxyzine and Wellbutrin Sr, by gender? *:

female:

Loss of consciousness
Malignant melanoma (skin cancer rises from melancytes)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pancreatitis (inflammation of pancreas)
Productive cough
Red blood cell count decreased
Respiratory tract infection
Scleral discolouration (change colour of sclera)
Stomatitis (inflammation of mucous membrane of mouth)
Streptococcal infection

male:

Somnolence (a state of near-sleep, a strong desire for sleep)
Type 2 diabetes mellitus
Adverse drug reaction
Alopecia (absence of hair from areas of the body)
Back disorder
Blood cholesterol increased
Blood sodium increased
Congestive cardiomyopathy (weakening of heart muscle)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

What are the common drug interactions of Hydroxyzine and Wellbutrin Sr, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Adverse drug reaction
Pain

20-29:

Memory impairment
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Panic disorder
Suicidal ideation
Allergy to animal
Allergy to plants
Mycotic allergy (fungal allergy)
Periodic limb movement disorder
Abdominal discomfort
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

30-39:

Weight increased
Deafness
Ear infection
Hypertension (high blood pressure)
Chest pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal pain

40-49:

Type 2 diabetes mellitus
Somnolence (a state of near-sleep, a strong desire for sleep)
Anaemia (lack of blood)
Bipolar disorder (mood disorder)
Blood pressure decreased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Headache (pain in head)
Self-injurious ideation
Suicidal ideation
Therapeutic response unexpected

50-59:

Red blood cell count decreased
Staphylococcal infection (an infection with staphylococcus bacteria)
Stomatitis (inflammation of mucous membrane of mouth)
Suicidal ideation
Surgery
Tinnitus (a ringing in the ears)
Weakness
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Diarrhoea
Pneumonia

60+:

Tinnitus (a ringing in the ears)
Tooth disorder (tooth disease)
Blood sodium increased
Candidiasis (candidiasis or thrush is a fungal infection)
Chills (felling of cold)
Confusional state
Conjunctival discolouration
Contusion (a type of hematoma of tissue in which capillaries)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 14.13%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 14.13%
Bipolar Disorder (mood disorder): 10 people, 10.87%
Drowsiness: 9 people, 9.78%
Insomnia (sleeplessness): 7 people, 7.61%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 6 people, 6.52%
Sleep Disorder: 5 people, 5.43%

* Approximation only. Some reports may have incomplete information.

Do you take Hydroxyzine and Wellbutrin sr?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously