Ibuprofen and Promethazine w/ codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ibuprofen (ibuprofen) and Promethazine w/ codeine (codeine phosphate; promethazine hydrochloride). Common drug interactions include hepatic failure among females and tendon rupture among males.

The phase IV clinical study analyzes what interactions people have when they take Ibuprofen and Promethazine w/ codeine. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,270 Ibuprofen users. Check the latest studies of Ibuprofen.

What is Promethazine w/ codeine?

Promethazine w/ codeine has active ingredients of codeine phosphate; promethazine hydrochloride. It is often used in cough. eHealthMe is studying from 279 Promethazine w/ codeine users. Check the latest studies of Promethazine w/ codeine.

On Jul, 29, 2026

37 people who take Ibuprofen and Promethazine w/ codeine together, and have interactions are studied.

Ibuprofen and Promethazine w/ codeine drug interactions.

What are the common drug interactions of Ibuprofen and Promethazine W/ Codeine, by gender? *:

female:

Hepatic failure (liver failure)
Rash
Renal failure acute (rapid kidney dysfunction)
Septic shock (shock due to blood infection)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Abdominal pain upper
Abdominal discomfort
Anaemia (lack of blood)
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

male:

Tendon rupture (tear of tendon)
Tendonitis (a condition that causes pain and swelling of tendons)
Tremor (trembling or shaking movements in one or more parts of your body)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dystonia (abnormal muscle tone)
Emotional disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Suicide attempt

What are the common drug interactions of Ibuprofen and Promethazine W/ Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder disorder
Gallbladder pain
Abdominal pain
Lichenoid keratosis (a skin disorder described by rapid growing, reddish to brown, benign (noncancerous) lesion on the skin)
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)
Abdominal pain upper
Drug eruption (adverse drug reaction of the skin)
Ovarian cyst (fluid filled sac of the ovary)

20-29:

Cholecystitis chronic (long lasting infection of gallbladder)
Gallbladder disorder
Post procedural diarrhoea
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Depression
Disturbance in attention
Emotional distress
Eyelid ptosis (falling of the upper or lower eyelid)

30-39:

Tendon rupture (tear of tendon)
Tendonitis (a condition that causes pain and swelling of tendons)

40-49:

Hepatic failure (liver failure)
Rash
Renal failure acute (rapid kidney dysfunction)
Septic shock (shock due to blood infection)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Abdominal discomfort
Abdominal pain upper
Anaemia (lack of blood)
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

50-59:

Contusion (a type of hematoma of tissue in which capillaries)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Mood swings (an extreme or rapid change in mood)
Erythema (redness of the skin)
Inflammation
Oedema peripheral (superficial swelling)
Skin warm
Suicide attempt

60+:

n/a

What are the existing conditions these people have? *

Depression: 14 people, 37.84%
Stress And Anxiety: 12 people, 32.43%
Birth Control: 11 people, 29.73%
Dyspnea (difficult or laboured breathing): 10 people, 27.03%
Dry Skin: 10 people, 27.03%
Upper Respiratory Tract Infection: 10 people, 27.03%
Hiv Infection: 10 people, 27.03%
Bipolar Disorder (mood disorder): 10 people, 27.03%
Diarrhea: 10 people, 27.03%
Sleep Disorder: 7 people, 18.92%

* Approximation only. Some reports may have incomplete information.

Do you take Ibuprofen and Promethazine w/ codeine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously