Imipramine hydrochloride and Modafinil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imipramine hydrochloride (imipramine hydrochloride) and Modafinil (modafinil). Common drug interactions include aphonia among females and dry mouth among males.

The phase IV clinical study analyzes what interactions people have when they take Imipramine hydrochloride and Modafinil. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Imipramine hydrochloride?

Imipramine hydrochloride has active ingredients of imipramine hydrochloride. It is often used in depression. eHealthMe is studying from 920 Imipramine hydrochloride users. Check the latest studies of Imipramine hydrochloride.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

On Jul, 21, 2026

26 people who take Imipramine hydrochloride and Modafinil together, and have interactions are studied.

Imipramine hydrochloride and Modafinil drug interactions.

What are the common drug interactions of Imipramine Hydrochloride and Modafinil, by gender? *:

female:

Aphonia (inability to produce voice)
Balance disorder
Breath sounds
Bronchial disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Burning sensation
Cardiac failure congestive
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)

male:

Dry mouth
Abnormal dreams
Head discomfort
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Weight decreased
Tooth abscess (pus formation in tooth)
Aphonia (inability to produce voice)
Breath sounds
Chest pain
Cough

What are the common drug interactions of Imipramine Hydrochloride and Modafinil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Balance disorder
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Sleep-related eating disorder (abnormal eating patterns during the night)
Somnambulism (sleep walking)
Weight increased

30-39:

Arthralgia (joint pain)
Asthenia (weakness)
Dizziness
Fatigue (feeling of tiredness)
Impaired healing
Joint swelling
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
Suicidal ideation
Tooth abscess (pus formation in tooth)

40-49:

Abscess oral (abscess in the mouth)
Cellulitis (infection under the skin)
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
Substance abuse
Burning sensation
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
Dysuria (painful or difficult urination)
Enuresis (repeated inability to control urination)
Pain
Photopsia (presence of perceived flashes of light)

50-59:

Pain
Phlebitis (inflammation of the walls of a vein)
Sleep paralysis (waking up and unable to move or speak)
Snoring
Tooth abscess (pus formation in tooth)
Tooth extraction
Weight decreased
Abnormal dreams
Aphonia (inability to produce voice)
Back pain

60+:

Dry mouth
Back pain
Cough
Head discomfort
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest pain
Hypoaesthesia (reduced sense of touch or sensation)
Dyspnoea (difficult or laboured respiration)
Aphonia (inability to produce voice)
Breath sounds

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 20 people, 76.92%
High Blood Pressure: 4 people, 15.38%
Stress And Anxiety: 3 people, 11.54%
Drowsiness: 3 people, 11.54%
Nightmares (unpleasant dreams): 2 people, 7.69%
Joint Pain: 2 people, 7.69%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 7.69%
High Blood Cholesterol: 2 people, 7.69%
Cerebral Ischaemia (insufficient blood flow to the brain to meet metabolic demand): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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