Indomethacin and Prograf drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Indomethacin (indomethacin) and Prograf (tacrolimus). Common drug interactions include interstitial lung disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Indomethacin and Prograf. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Indomethacin?

Indomethacin has active ingredients of indomethacin. It is often used in gout. eHealthMe is studying from 16,884 Indomethacin users. Check the latest studies of Indomethacin.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.



On Jul, 20, 2026

19 people who take Indomethacin and Prograf together, and have interactions are studied.

Indomethacin and Prograf drug interactions.

What are the common drug interactions of Indomethacin and Prograf, by gender? *:

female:

  1. Interstitial lung disease
  2. Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
  3. Cardiac failure
  4. Cardiac failure congestive
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Pleural effusion (water on the lungs)
  7. Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
  8. Respiratory failure (inadequate gas exchange by the respiratory system)
  9. Blood beta-d-glucan increased
  10. Cardiomegaly (increased size of heart than normal)

male:

  1. Chronic kidney disease
  2. Fall
  3. Hospitalisation
  4. Aortic valve disease mixed
  5. Bicuspid aortic valve
  6. Cerebral infarction (less blood supply to brain resulting tissue damage)
  7. Dizziness
  8. Dyspepsia (indigestion)
  9. Dysstasia (difficulty in standing)
  10. Gouty arthritis (joint inflammation with crystal formation)

What are the common drug interactions of Indomethacin and Prograf, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Cardiac failure congestive
  2. Cardiomegaly (increased size of heart than normal)
  3. Chronic kidney disease
  4. Nephrogenic anaemia (anaemia due to kidney disease)
  5. Renal failure (kidney dysfunction)
  6. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  7. Dyspepsia (indigestion)
  8. Fall
  9. Necrosis (the death of body tissue)
  10. Nuclear magnetic resonance imaging brain

50-59:

  1. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  2. Coronary artery bypass
  3. Fall
  4. Incontinence (lack of moderation or self-control)
  5. Mitral valve replacement
  6. Aortic valve disease mixed
  7. Bicuspid aortic valve
  8. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  9. Gouty arthritis (joint inflammation with crystal formation)
  10. Hyperlipidaemia (presence of excess lipids in the blood)

60+:

  1. Interstitial lung disease
  2. Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
  3. Rheumatoid lung (blockage of the small airways of the lung associated with rheumatoid arthritis)
  4. Cerebral infarction (less blood supply to brain resulting tissue damage)
  5. Dizziness
  6. Drug hypersensitivity
  7. Drug ineffective
  8. Dysstasia (difficulty in standing)
  9. Eating disorder
  10. Nerve injury

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 31.58%
  2. Immunodeficiency Disorders: 3 people, 15.79%
  3. Indigestion: 2 people, 10.53%
  4. High Blood Cholesterol: 1 person, 5.26%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.26%
  6. Cardiac Disorder: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Indomethacin and Prograf:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Indomethacin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Prograf:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Indomethacin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Prograf and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on indomethacin and tacrolimus (the active ingredients of Indomethacin and Prograf, respectively), and Indomethacin and Prograf (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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