Invanz and Digoxin drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Invanz (ertapenem sodium) and Digoxin (digoxin). Common drug interactions include emotional distress among females and blister among males.
The phase IV clinical study analyzes what interactions people have when they take Invanz and Digoxin. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.
What is Invanz?
Invanz has active ingredients of ertapenem sodium. It is often used in urinary tract infection. eHealthMe is studying from 3,961 Invanz users. Check the latest studies of Invanz.
What is Digoxin?
Digoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 93,740 Digoxin users. Check the latest studies of Digoxin.
55 people who take Invanz and Digoxin together, and have interactions are studied.

What are the common drug interactions of Invanz and Digoxin, by gender? *:
female:
- Emotional distress
- Fibula fracture
- Flushing (the warm, red condition of human skin)
- General physical health deterioration (weak health status)
- Headache (pain in head)
- Ileal stenosis (obstruction in the ileal)
- Ileus (a painful obstruction of the ileum or other part of the intestine)
- Impaired healing
- Jaw fracture
- Oedema peripheral (superficial swelling)
male:
- Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
- Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
- Platelet count decreased
- Seizure (abnormal excessive or synchronous neuronal activity in the brain)
- Sepsis (a severe blood infection that can lead to organ failure and death)
- Thrombocytopenia (decrease of platelets in blood)
- Oedema peripheral (superficial swelling)
- Anaemia (lack of blood)
- Anticonvulsant drug level decreased
- Asthenia (weakness)
What are the common drug interactions of Invanz and Digoxin, by age (0-1 to 60+)? *:
0-1:
- Dyspnoea (difficult or laboured respiration)
- Tachycardia (a heart rate that exceeds the range of 100 beats/min)
- Abdominal distension
- Abdominal pain upper
- Anaemia (lack of blood)
- Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
- Angioedema (rapid swelling of the dermis)
- Anxiety
- Arthritis (form of joint disorder that involves inflammation of one or more joints)
- Arthropathy
2-9:
n/a
10-19:
- Muscle spasms (muscle contraction)
- Thrombosis (formation of a blood clot inside a blood vessel)
- Abdominal distension
- Abdominal pain
- Abscess (pus)
- Actinic keratosis (skin disease due to sun exposure)
- Acute sinusitis
- Anogenital warts
- Anxiety
- Aortic calcification (aortic calcification sign of heart valve disease)
20-29:
n/a
30-39:
n/a
40-49:
- Hypotension (abnormally low blood pressure)
- Dizziness
- Dyspnoea (difficult or laboured respiration)
- Pain
- Pleural effusion (water on the lungs)
- Vomiting
- Syncope (loss of consciousness with an inability to maintain postural tone)
- Ascites (accumulation of fluid in the abdominal cavity)
- Abdominal discomfort
- Localised oedema (fluid retention in a particular part of the body)
50-59:
- Inflammation
- Lymphadenopathy (disease or enlargement of lymph nodes)
- Oedema peripheral (superficial swelling)
- Oral disorder (mouth disease)
- Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
- Anticonvulsant drug level decreased
- Drug ineffective
- Injury
- Spinal compression fracture (fracture due to spinal compression on bone)
- Tibia fracture (fracture of lower leg bone)
60+:
- Oedema peripheral (superficial swelling)
- Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
- Pulmonary oedema (fluid accumulation in the lungs)
- Agitation (state of anxiety or nervous excitement)
- Alanine aminotransferase increased
- Anaemia (lack of blood)
- Aspartate aminotransferase increased
- Asthenia (weakness)
- Confusional state
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
What are the existing conditions these people have? *
- Pulmonary Hypertension (increase in blood pressure in the lung artery): 18 people, 32.73%
- Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 10 people, 18.18%
- Traumatic Injury Of The Bladder And Urethra: 7 people, 12.73%
- Metastases To Bone (cancer spreads to bone): 6 people, 10.91%
- Oedema (fluid collection in tissue): 5 people, 9.09%
- Abdominal Sepsis (abdominal infection): 3 people, 5.45%
* Approximation only. Some reports may have incomplete information.
Do you take Invanz and Digoxin?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Invanz and Digoxin:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Invanz:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Digoxin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Invanz and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Digoxin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Guru SR, Suresh A, Padmanabhan S, Reddy A, "A Rare Case of Digoxin Associated Gingival Overgrowth", Journal of clinical and diagnostic research: JCDR, 2017 Jan .
- Lai SW, Lin CL, Liao KF, "Digoxin use may increase the relative risk of acute pancreatitis: a population-based case–control study in Taiwan", International journal of cardiology, 2015 Feb .
- Guru SR, Suresh A, Padmanabhan S, Reddy A, "A Rare Case of Digoxin Associated Gingival Overgrowth", Journal of clinical and diagnostic research: JCDR, 2017 Jan .
- Lai SW, Lin CL, Liao KF, "Digoxin use may increase the relative risk of acute pancreatitis: a population-based case–control study in Taiwan", International journal of cardiology, 2015 Feb .
How the study uses the data?
The study uses data from the FDA. It is based on ertapenem sodium and digoxin (the active ingredients of Invanz and Digoxin, respectively), and Invanz and Digoxin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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