Isosorbide dinitrate and Niacin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isosorbide dinitrate (isosorbide dinitrate) and Niacin (niacin). Common drug interactions include benign renal neoplasm among females and renal failure acute among males.

The phase IV clinical study analyzes what interactions people have when they take Isosorbide dinitrate and Niacin. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

What is Niacin?

Niacin has active ingredients of niacin. It is often used in high blood cholesterol. eHealthMe is studying from 9,009 Niacin users. Check the latest studies of Niacin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

65 people who take Isosorbide dinitrate and Niacin together, and have interactions are studied.

Isosorbide dinitrate and Niacin drug interactions.

What are the common drug interactions of Isosorbide Dinitrate and Niacin, by gender? *:

female:

Benign renal neoplasm (benign (non-cancerous) tumours of the kidney)
Bladder disorder
Blood creatine phosphokinase mm increased
Blood creatinine increased
Blood homocysteine
Blood urea increased
Blood urine present
Bradycardia (abnormally slow heart action)
Breast mass
Carotid artery occlusion (artery blockage)

male:

Renal failure acute (rapid kidney dysfunction)
Dehydration (dryness resulting from the removal of water)
Cardiomegaly (increased size of heart than normal)
Cystitis (inflammation of the wall of the bladder)
Decreased interest
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Impaired healing
Intermittent claudication
Pain in extremity
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)

What are the common drug interactions of Isosorbide Dinitrate and Niacin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hepatic enzyme increased

50-59:

Anaemia (lack of blood)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Thrombocytopenia (decrease of platelets in blood)

60+:

Renal failure acute (rapid kidney dysfunction)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Haemoglobin decreased
Abdominal pain
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Cystitis (inflammation of the wall of the bladder)
Decreased interest
Impaired healing
Intermittent claudication
Pain in extremity

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 8 people, 12.31%
Type 2 Diabetes: 7 people, 10.77%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 10.77%
Cardiac Disorder: 6 people, 9.23%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 7.69%
Stable Angina (a constant chest pain): 4 people, 6.15%
High Blood Pressure: 4 people, 6.15%
Diabetes: 4 people, 6.15%
Cardiac Failure Congestive: 4 people, 6.15%

* Approximation only. Some reports may have incomplete information.

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