Isosorbide mononitrate and Zanaflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isosorbide mononitrate (isosorbide mononitrate) and Zanaflex (tizanidine hydrochloride). Common drug interactions include sepsis among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Isosorbide mononitrate and Zanaflex. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Isosorbide mononitrate?

Isosorbide mononitrate has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 26,858 Isosorbide mononitrate users. Check the latest studies of Isosorbide mononitrate.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

On Jul, 06, 2026

53 people who take Isosorbide mononitrate and Zanaflex together, and have interactions are studied.

Isosorbide mononitrate and Zanaflex drug interactions.

What are the common drug interactions of Isosorbide Mononitrate and Zanaflex, by gender? *:

female:

Sepsis (a severe blood infection that can lead to organ failure and death)
Back pain
Activities of daily living impaired
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Acute left ventricular failure (heart attack)
Acute myocardial infarction (acute heart attack)
Acute respiratory failure
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Apathy

male:

Arthralgia (joint pain)
Head injury
Headache (pain in head)
Influenza
Nasopharyngitis (inflammation of the nasopharynx)
Acute respiratory failure
Adverse event
Blood cholesterol increased
Blood glucose decreased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the common drug interactions of Isosorbide Mononitrate and Zanaflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Constipation
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematemesis (vomiting of blood)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Rectal haemorrhage (bleeding from anus)

40-49:

Constipation

50-59:

Sepsis (a severe blood infection that can lead to organ failure and death)
Acute myocardial infarction (acute heart attack)
Acute respiratory failure
Adverse event
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood creatinine increased
Breast cancer
Cardiac disorder
Chest discomfort
Chest pain

60+:

Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cellulitis (infection under the skin)
Contusion (a type of hematoma of tissue in which capillaries)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Embolism venous (embolus may pass into the arterial system)
Essential hypertension (primary hypertension)
Fall
Hypercholesterolaemia (high levels of cholesterol in the blood)

What are the existing conditions these people have? *

Pain: 17 people, 32.08%
High Blood Pressure: 10 people, 18.87%
Cardiac Disorder: 8 people, 15.09%
Depression: 8 people, 15.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 15.09%
Multiple Myeloma (cancer of the plasma cells): 6 people, 11.32%
Cough: 6 people, 11.32%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 11.32%
Neuropathy Peripheral (surface nerve damage): 6 people, 11.32%
High Blood Cholesterol: 6 people, 11.32%

* Approximation only. Some reports may have incomplete information.

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