Janumet and Leflunomide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Janumet (metformin hydrochloride; sitagliptin phosphate) and Leflunomide (leflunomide). Common drug interactions include general physical health deterioration among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Janumet and Leflunomide. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Janumet?

Janumet has active ingredients of metformin hydrochloride; sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 25,023 Janumet users. Check the latest studies of Janumet.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

On Jul, 11, 2026

96 people who take Janumet and Leflunomide together, and have interactions are studied.

Janumet and Leflunomide drug interactions.

What are the common drug interactions of Janumet and Leflunomide, by gender? *:

female:

General physical health deterioration (weak health status)
Grip strength decreased
Hypokinesia (decreased bodily movement)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Pericarditis (inflammation of the pericardium)
Renal failure (kidney dysfunction)
Spinal pain (pain in spine)
Cardiac valve disease (heart valve disease)
Arthropathy
Drug ineffective

male:

Pain
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Cellulitis (infection under the skin)
Diarrhoea
Faeces pale
Haematemesis (vomiting of blood)
Hypophagia (reduced food intake)
Intracardiac mass (cardiac mass)
Joint swelling
Lipids increased (excess lipid in body)

What are the common drug interactions of Janumet and Leflunomide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Pain
Abdominal discomfort
Abdominal pain
Arthralgia (joint pain)
Cellulitis (infection under the skin)
Faeces pale
Haematemesis (vomiting of blood)
Hypophagia (reduced food intake)
Intracardiac mass (cardiac mass)
Lymphoma (cancer that begins in immune system cells)

50-59:

Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)
Pyrexia (fever)
Throat tightness
Tremor (trembling or shaking movements in one or more parts of your body)
Visual impairment
Weight decreased
Pain
Pneumonia
Rash

60+:

Urinary tract infection
Arthralgia (joint pain)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Injection site bruising
Injection site pain
Oropharyngeal pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Stress
Visual impairment
Blood pressure increased

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 29 people, 30.21%
High Blood Pressure: 13 people, 13.54%
Type 2 Diabetes: 7 people, 7.29%
Pain: 5 people, 5.21%
High Blood Cholesterol: 5 people, 5.21%

* Approximation only. Some reports may have incomplete information.

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