Keppra xr and Spironolactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Keppra xr (levetiracetam) and Spironolactone (spironolactone). Common drug interactions include muscle spasms among females and arrhythmia among males.

The phase IV clinical study analyzes what interactions people have when they take Keppra xr and Spironolactone. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Keppra xr?

Keppra xr has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 2,272 Keppra xr users. Check the latest studies of Keppra xr.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

On Jul, 16, 2026

14 people who take Keppra xr and Spironolactone together, and have interactions are studied.

Keppra xr and Spironolactone drug interactions.

What are the common drug interactions of Keppra Xr and Spironolactone, by gender? *:

female:

Muscle spasms (muscle contraction)
Diarrhoea
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Fatigue (feeling of tiredness)
Abdominal pain
Alopecia (absence of hair from areas of the body)
Chest pain
Cough

male:

Arrhythmia (irregular heartbeat)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Fall
Head injury
Infection
Malignant melanoma (skin cancer rises from melancytes)
Overdose
Post procedural infection
Thyroid cancer

What are the common drug interactions of Keppra Xr and Spironolactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Muscle spasms (muscle contraction)

40-49:

Confusional state
Contusion (a type of hematoma of tissue in which capillaries)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fatigue (feeling of tiredness)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Head injury
Loss of consciousness
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Swelling
Tremor (trembling or shaking movements in one or more parts of your body)

50-59:

Diarrhoea
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Abdominal pain
Alopecia (absence of hair from areas of the body)
Chest pain
Constipation
Cough
Depressed mood

60+:

Arrhythmia (irregular heartbeat)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Thyroid cancer
Fall
Head injury
Infection
Malignant melanoma (skin cancer rises from melancytes)
Muscle spasms (muscle contraction)
Overdose
Post procedural infection

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 7 people, 50.00%
Pain: 3 people, 21.43%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 14.29%
Nail Infection: 2 people, 14.29%
Diarrhea: 2 people, 14.29%
Constipation: 2 people, 14.29%
Headache (pain in head): 2 people, 14.29%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 2 people, 14.29%
High Blood Pressure: 2 people, 14.29%
Urinary Tract Infection: 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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