Ketoconazole and Rapamune drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ketoconazole (ketoconazole) and Rapamune (sirolimus). Common drug interactions include thrombophlebitis superficial among females and lymphoma among males.

The phase IV clinical study analyzes what interactions people have when they take Ketoconazole and Rapamune. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Ketoconazole?

Ketoconazole has active ingredients of ketoconazole. It is often used in fungal infection. eHealthMe is studying from 16,014 Ketoconazole users. Check the latest studies of Ketoconazole.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.

On Jul, 19, 2026

18 people who take Ketoconazole and Rapamune together, and have interactions are studied.

Ketoconazole and Rapamune drug interactions.

What are the common drug interactions of Ketoconazole and Rapamune, by gender? *:

female:

Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Venous thrombosis limb (blood clot that forms in a vein in the limb)
Blood bicarbonate decreased
Blood lactate dehydrogenase increased
Blood potassium increased
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Feeling cold
Gastritis (inflammation of stomach)
Headache (pain in head)

male:

Lymphoma (cancer that begins in immune system cells)
Neutropenia (an abnormally low number of neutrophils)
Blood chloride decreased
Blood potassium increased
Blood pressure decreased
Blood sodium decreased
Body temperature increased
Cardiac murmur (an heart sound in valve abnormality)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chest pain

What are the common drug interactions of Ketoconazole and Rapamune, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood bicarbonate decreased
Blood lactate dehydrogenase increased
Blood potassium increased
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Feeling cold
Gastritis (inflammation of stomach)
Headache (pain in head)
Hypochromic anaemia (hypochromic anaemia is a generic term for any type of anaemia in which the red blood cells (erythrocytes) are paler than normal)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

30-39:

n/a

40-49:

Muscle fatigue (a condition in which muscles cannot exert their normal force)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Venous thrombosis limb (blood clot that forms in a vein in the limb)
Orthostatic hypertension (a medical condition consisting of a sudden increase in blood pressure when a person stands up)
Abdominal discomfort
Anaemia (lack of blood)
Blood carbon dioxide decreased
Blood chloride decreased
Blood potassium increased
Blood sodium decreased

50-59:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chest pain
Dyspnoea (difficult or laboured respiration)
Fluid overload (too much fluid in the blood)
Hypertension (high blood pressure)
Hypoxia (low oxygen in tissues)
Lymphoma (cancer that begins in immune system cells)
Neutropenia (an abnormally low number of neutrophils)
Pleural effusion (water on the lungs)

60+:

Lymphoma (cancer that begins in immune system cells)
Neutropenia (an abnormally low number of neutrophils)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Histiocytosis (a blood disease characterized by an abnormal multiplication of macrophages)
Hypertension (high blood pressure)
Hyperviscosity syndrome (a condition in which blood is not able to flow freely through your arteries)
Kidney transplant rejection
Multi-organ failure (multisystem organ failure)
Renal disorder (kidney disease)

What are the existing conditions these people have? *

Gout (uric acid crystals building up in the body): 4 people, 22.22%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 4 people, 22.22%
High Blood Pressure: 3 people, 16.67%
Chronic Kidney Disease: 3 people, 16.67%
Immunodeficiency Disorders: 2 people, 11.11%
Colon Cancer Metastatic (cancer of colon spreads to other part of body): 2 people, 11.11%
Sepsis (a severe blood infection that can lead to organ failure and death): 1 person, 5.56%
Renal Disorder (kidney disease): 1 person, 5.56%
Procedural Hypertension: 1 person, 5.56%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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