Keytruda and Ciprofloxacin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Keytruda (pembrolizumab) and Ciprofloxacin (ciprofloxacin). Common drug interactions include abnormal loss of weight among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Keytruda and Ciprofloxacin. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

What is Ciprofloxacin?

Ciprofloxacin has active ingredients of ciprofloxacin. It is often used in urinary tract infection. eHealthMe is studying from 22,256 Ciprofloxacin users. Check the latest studies of Ciprofloxacin.

On Aug, 13, 2026

24 people who take Keytruda and Ciprofloxacin together, and have interactions are studied.

Keytruda and Ciprofloxacin drug interactions.

What are the common drug interactions of Keytruda and Ciprofloxacin, by gender? *:

female:

Abnormal loss of weight
Diarrhoea
Vomiting
Mixed liver injury
Back pain
Constipation
Decreased appetite
Dizziness
Hypoglycaemia (deficiency of glucose in the bloodstream)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

male:

Dyspnoea (difficult or laboured respiration)
Asthenia (weakness)
Rash erythematous (redness of the skin)
Rash pruritic (redness with itching)
Rash vesicular (rash with a small bubble)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Skin exfoliation (removal of the oldest dead skin cells)
Somnolence (a state of near-sleep, a strong desire for sleep)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the common drug interactions of Keytruda and Ciprofloxacin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Constipation
Decreased appetite
Dizziness
Hypoglycaemia (deficiency of glucose in the bloodstream)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)
Secondary adrenocortical insufficiency (inadequate secretion of acth by the pituitary gland)
Weight decreased

30-39:

Rash
Skin necrosis (skin damage)
Vascular purpura (haemorrhages in the skin and mucous membranes that result in the appearance of purplish spots or patches)

40-49:

n/a

50-59:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Pallor
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Somnolence (a state of near-sleep, a strong desire for sleep)

60+:

Abnormal loss of weight
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Electrolyte imbalance
Immune system disorder
Infusion related reaction
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Oral mucosal exfoliation (removal of mucous membrane of mouth)

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 5 people, 20.83%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 5 people, 20.83%
Insomnia (sleeplessness): 4 people, 16.67%
Breast Cancer: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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