L-methylfolate and Fenofibrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take L-methylfolate (folic acid) and Fenofibrate (fenofibrate). Common drug interactions include fatigue among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take L-methylfolate and Fenofibrate. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is L-methylfolate?

L-methylfolate has active ingredients of folic acid. It is often used in depression. eHealthMe is studying from 619 L-methylfolate users. Check the latest studies of L-methylfolate.

What is Fenofibrate?

Fenofibrate has active ingredients of fenofibrate. It is often used in high blood cholesterol. eHealthMe is studying from 40,457 Fenofibrate users. Check the latest studies of Fenofibrate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

11 people who take L-methylfolate and Fenofibrate together, and have interactions are studied.

L-methylfolate and Fenofibrate drug interactions.

What are the common drug interactions of L-Methylfolate and Fenofibrate, by gender? *:

female:

Fatigue (feeling of tiredness)
Haematoma (collection of blood outside the blood vessels)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Agitation (state of anxiety or nervous excitement)
Anxiety
Arthralgia (joint pain)

male:

Anxiety
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Blood pressure increased
Drug effect decreased
Hypertension (high blood pressure)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

What are the common drug interactions of L-Methylfolate and Fenofibrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anxiety
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Blood pressure increased
Drug effect decreased
Hypertension (high blood pressure)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

50-59:

Fall
Foot fracture
Ligament sprain (ligament stretched)
Migraine (headache)
Nasopharyngitis (inflammation of the nasopharynx)
Osteoporosis (bones weak and more likely to break)
Poor quality sleep
Weight decreased

60+:

Asthenia (weakness)
Chronic kidney disease
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Agitation (state of anxiety or nervous excitement)
Anxiety
Arthralgia (joint pain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state
Deafness

What are the existing conditions these people have? *

Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 27.27%
Stress And Anxiety: 2 people, 18.18%
Sleep Disorder: 2 people, 18.18%
Blood Glucose Abnormal: 2 people, 18.18%
Chest Pain: 2 people, 18.18%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 2 people, 18.18%
Diabetes: 2 people, 18.18%
Diarrhea: 2 people, 18.18%
Gastric Disorder (disease of stomach): 2 people, 18.18%
Gastric Ulcer (stomach ulcer): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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