Lactobacillus and Methotrexate sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lactobacillus (lactobacillus) and Methotrexate sodium (methotrexate sodium). Common drug interactions include knee arthroplasty among females and acute respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Lactobacillus and Methotrexate sodium. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Lactobacillus?

Lactobacillus has active ingredients of lactobacillus. It is often used in stomach discomfort. eHealthMe is studying from 5,854 Lactobacillus users. Check the latest studies of Lactobacillus.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,679 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.



On Jul, 10, 2026

37 people who take Lactobacillus and Methotrexate sodium together, and have interactions are studied.

Lactobacillus and Methotrexate sodium drug interactions.

What are the common drug interactions of Lactobacillus and Methotrexate Sodium, by gender? *:

female:

  1. Knee arthroplasty
  2. Rash
  3. Arthropathy
  4. Lower respiratory tract infection
  5. Abdominal discomfort
  6. Drug abuse
  7. Overdose
  8. Obesity (having too much body fat)
  9. Diarrhoea
  10. Pain in extremity

male:

  1. Acute respiratory failure
  2. Arthralgia (joint pain)
  3. Joint swelling
  4. Lung adenocarcinoma (a form of non-small cell lung cancer)
  5. Lung neoplasm malignant (cancer tumour of lung)
  6. Mitral valve incompetence (inefficient heart valve)
  7. Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
  8. Oedema peripheral (superficial swelling)
  9. Osteopenia (a condition where bone mineral density is lower than normal)
  10. Pain in extremity

What are the common drug interactions of Lactobacillus and Methotrexate Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Adenovirus infection
  2. Cytomegalovirus test positive
  3. Diarrhoea
  4. Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
  5. Hyperglycaemia (high blood sugar)
  6. Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
  7. Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
  8. Respiratory disorder (respiratory disease)
  9. Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Diarrhoea
  2. Productive cough
  3. Bone density decreased
  4. Cellulitis (infection under the skin)
  5. Ear pain
  6. Hypoacusis (loss of hearing)
  7. Neutropenia (an abnormally low number of neutrophils)
  8. Pain in extremity
  9. Weight decreased
  10. Weight increased

60+:

  1. Knee arthroplasty
  2. Rash
  3. Ear disorder
  4. Hepatic enzyme increased
  5. Nasopharyngitis (inflammation of the nasopharynx)
  6. Nausea (feeling of having an urge to vomit)
  7. Wheezing (a high-pitched whistling sound made while you breath)
  8. Wrist fracture
  9. Pain in extremity
  10. Anaemia (lack of blood)

What are the existing conditions these people have? *

  1. Pituitary Tumor: 23 people, 62.16%
  2. Empty Sella Syndrome (pituitary gland shrinks or becomes flattened): 23 people, 62.16%
  3. Depression: 23 people, 62.16%
  4. Abdominal Discomfort: 23 people, 62.16%
  5. Pain: 5 people, 13.51%
  6. Vasculitis (inflammation of a blood vessel or blood vessels): 3 people, 8.11%
  7. High Blood Pressure: 3 people, 8.11%
  8. Lower Respiratory Tract Infection: 2 people, 5.41%
  9. Joint Pain: 2 people, 5.41%
  10. Gastric Ulcer (stomach ulcer): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Lactobacillus and Methotrexate sodium?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Lactobacillus and Methotrexate sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lactobacillus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Methotrexate sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lactobacillus and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Methotrexate sodium and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on lactobacillus and methotrexate sodium (the active ingredients of Lactobacillus and Methotrexate sodium, respectively), and Lactobacillus and Methotrexate sodium (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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