Lamictal and Fiorinal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lamictal (lamotrigine) and Fiorinal (aspirin; butalbital; caffeine). Common drug interactions include nasopharyngitis among females and flank pain among males.

The phase IV clinical study analyzes what interactions people have when they take Lamictal and Fiorinal. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Lamictal?

Lamictal has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 82,626 Lamictal users. Check the latest studies of Lamictal.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

On Jul, 19, 2026

30 people who take Lamictal and Fiorinal together, and have interactions are studied.

Lamictal and Fiorinal drug interactions.

What are the common drug interactions of Lamictal and Fiorinal, by gender? *:

female:

Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Neck pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Perineurial cyst
Poor quality sleep
Pyrexia (fever)
Rash erythematous (redness of the skin)
Rash macular (small, flat red spots)

male:

Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Hidradenitis (chronic disease of a type of sweat gland)
Vomiting
Post procedural complication
Spinal fusion surgery
Surgery
Alopecia (absence of hair from areas of the body)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Brain mass
Diplopia (double vision)

What are the common drug interactions of Lamictal and Fiorinal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Aspartate aminotransferase increased
Balance disorder
C-reactive protein increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Depression
Diarrhoea
General physical health deterioration (weak health status)
Hyperhidrosis (abnormally increased sweating)
Hyperventilation
Hypotension (abnormally low blood pressure)

30-39:

Alopecia (absence of hair from areas of the body)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Brain mass
Diplopia (double vision)
Dyspnoea (difficult or laboured respiration)
Eye movement disorder
Feeling jittery
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Incoherent (talking in a confused and unclear way)
Insomnia (sleeplessness)

40-49:

Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Hidradenitis (chronic disease of a type of sweat gland)
Injection site haemorrhage (bleeding from injection site)
Injection site pain
Mobility decreased (ability to move is reduced)
Nephrolithiasis (calculi in the kidneys)
Nerve compression
Pain
Post procedural discharge
Spinal fracture (fracture in one of vertebrae)

50-59:

Weight decreased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hypertension (high blood pressure)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Balance disorder
Blood immunoglobulin a decreased
Blood immunoglobulin g decreased
Blood immunoglobulin m decreased
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Cystitis (inflammation of the wall of the bladder)

60+:

Anaphylactic reaction (serious allergic reaction)
Back disorder
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Nervousness
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Tension (the act or process of stretching something tight)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 26.67%
Pain: 6 people, 20.00%
Depression: 5 people, 16.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 13.33%
Headache (pain in head): 4 people, 13.33%
High Blood Pressure: 4 people, 13.33%
Hypersensitivity: 4 people, 13.33%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 13.33%
Muscle Spasms (muscle contraction): 3 people, 10.00%
Insomnia (sleeplessness): 3 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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