Lanoxin and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lanoxin (digoxin) and Diphen (diphenhydramine hydrochloride). Common drug interactions include aspartate aminotransferase increased among females and renal failure acute among males.

The phase IV clinical study analyzes what interactions people have when they take Lanoxin and Diphen. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Lanoxin?

Lanoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 21,852 Lanoxin users. Check the latest studies of Lanoxin.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

On Jul, 20, 2026

57 people who take Lanoxin and Diphen together, and have interactions are studied.

What are the common drug interactions of Lanoxin and Diphen, by gender? *:

female:

Aspartate aminotransferase increased
Asthenia (weakness)
Asthma
Blood creatinine increased
Blood lactic acid increased
Blood magnesium decreased
Blood potassium decreased
Blood pressure decreased
Blood sodium decreased
Blood uric acid increased

male:

Renal failure acute (rapid kidney dysfunction)
Arrhythmia (irregular heartbeat)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Hepatic failure (liver failure)
Liver disorder (liver diseases)
Pneumonia
Pulmonary hypertension (increase in blood pressure in the lung artery)
Septic shock (shock due to blood infection)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Lanoxin and Diphen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiac arrest
Dysstasia (difficulty in standing)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cough
Depression
Disability
Fear
Infection
Injury

50-59:

Hepatic failure (liver failure)
Liver disorder (liver diseases)
Renal failure acute (rapid kidney dysfunction)
Septic shock (shock due to blood infection)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Serratia bacteraemia (bacterial blood infection)
Staphylococcal bacteraemia (a bacterial infection of blood)
Thrombocytopenia (decrease of platelets in blood)
Thrombosis (formation of a blood clot inside a blood vessel)

60+:

Malaise (a feeling of general discomfort or uneasiness)
Staphylococcal infection (an infection with staphylococcus bacteria)
Sinusitis (inflammation of sinus)
Urine flow decreased
Asthenia (weakness)
Back pain
Blood pressure decreased
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 8 people, 14.04%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 8.77%
Type 2 Diabetes: 3 people, 5.26%
Pain: 3 people, 5.26%
Lung Neoplasm Malignant (cancer tumour of lung): 3 people, 5.26%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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