Lansoprazole and Rybelsus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lansoprazole (lansoprazole) and Rybelsus (semaglutide). Common drug interactions include fatigue among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Lansoprazole and Rybelsus. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Lansoprazole?

Lansoprazole has active ingredients of lansoprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 129,663 Lansoprazole users. Check the latest studies of Lansoprazole.

What is Rybelsus?

Rybelsus has active ingredients of semaglutide. eHealthMe is studying from 4,159 Rybelsus users. Check the latest studies of Rybelsus.

On Jul, 07, 2026

15 people who take Lansoprazole and Rybelsus together, and have interactions are studied.

Lansoprazole and Rybelsus drug interactions.

What are the common drug interactions of Lansoprazole and Rybelsus, by gender? *:

female:

Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Dizziness
Dyspnoea (difficult or laboured respiration)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Osteomyelitis (infection of bone)
Osteonecrosis of jaw (death of bone of jaw)
Pulmonary embolism (blockage of the main artery of the lung)
Somnolence (a state of near-sleep, a strong desire for sleep)

male:

Dehydration (dryness resulting from the removal of water)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Prerenal failure
Rash erythematous (redness of the skin)
Vomiting
Abdominal discomfort
Angina pectoris (chest pain due to ischemia of the heart muscle)
Blood glucose increased
Ketoacidosis (high concentrations of ketone bodies in blood)
Rash pruritic (redness with itching)

What are the common drug interactions of Lansoprazole and Rybelsus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal distension
Glycosylated haemoglobin
Headache (pain in head)
Nausea (feeling of having an urge to vomit)

40-49:

Diarrhoea
Prerenal failure
Vomiting
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Dizziness
Somnolence (a state of near-sleep, a strong desire for sleep)
Vaginal haemorrhage (vaginal bleeding)

50-59:

Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Lactic acidosis (low ph in body tissues)
Rash erythematous (redness of the skin)
Blood glucose increased
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Ketoacidosis (high concentrations of ketone bodies in blood)
Osteomyelitis (infection of bone)
Osteonecrosis of jaw (death of bone of jaw)
Pulmonary embolism (blockage of the main artery of the lung)
Toothache (tooth pain)

60+:

Fatigue (feeling of tiredness)
Asthenia (weakness)
Hyperhidrosis (abnormally increased sweating)
Abdominal discomfort
Angina pectoris (chest pain due to ischemia of the heart muscle)
Dyspnoea (difficult or laboured respiration)
Rash pruritic (redness with itching)
Throat tightness
Weight decreased

What are the existing conditions these people have? *

Type 2 Diabetes: 4 people, 26.67%
Diabetes: 3 people, 20.00%
Ill-Defined Disorder: 2 people, 13.33%
High Blood Cholesterol: 1 person, 6.67%
Breast Cancer: 1 person, 6.67%
Cerebral Haemorrhage (bleeding within the brain): 1 person, 6.67%
Cushing's Syndrome (obesity, a rounded face, increased fat): 1 person, 6.67%
Dyslipidaemia (abnormal amount of lipids): 1 person, 6.67%
Ear Disorder: 1 person, 6.67%
High Blood Pressure: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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