Levaquin and Tykerb drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levaquin (levofloxacin) and Tykerb (lapatinib ditosylate). Common drug interactions include metastases to central nervous system among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Levaquin and Tykerb. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

What is Tykerb?

Tykerb has active ingredients of lapatinib ditosylate. It is often used in breast cancer. eHealthMe is studying from 12,231 Tykerb users. Check the latest studies of Tykerb.

On Jul, 26, 2026

46 people who take Levaquin and Tykerb together, and have interactions are studied.

What are the common drug interactions of Levaquin and Tykerb, by gender? *:

female:

Metastases to central nervous system (cancer spreads to central nervous system)
Metastases to liver (cancer spreads to liver)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Metastases to lung (cancer spreads to lung)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Vomiting
Osteonecrosis of jaw (death of bone of jaw)
Rash
Tooth extraction

male:

Anxiety
Injury
Dyspnoea (difficult or laboured respiration)
Metastases to lung (cancer spreads to lung)
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Spinal haemangioma (an abnormal, but non cancer blood vessel tumour that commonly occurs in the spine)
Vomiting
Aortic valve incompetence
Arthralgia (joint pain)

What are the common drug interactions of Levaquin and Tykerb, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Neutropenia (an abnormally low number of neutrophils)
Thrombocytopenia (decrease of platelets in blood)
Acne (skin problems that cause pimples)
Alopecia (absence of hair from areas of the body)
Anal fissure
Anogenital warts
Anxiety
Bacterial infection
Bone erosion
Bone sarcoma (bone cancer)

40-49:

Constipation
Metastases to bone (cancer spreads to bone)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Anaemia (lack of blood)
Anxiety
Cough
Deformity (disfigurement)
Emotional distress
Hypoaesthesia (reduced sense of touch or sensation)
Metastases to liver (cancer spreads to liver)

50-59:

Hypoaesthesia (reduced sense of touch or sensation)
Anxiety
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypotension (abnormally low blood pressure)
Injury
Metastases to bone (cancer spreads to bone)
Metastases to central nervous system (cancer spreads to central nervous system)
Metastases to lung (cancer spreads to lung)
Weight decreased
Abdominal pain

60+:

Decreased appetite
Diarrhoea
Back pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cough
Febrile neutropenia (fever with reduced white blood cells)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypoaesthesia (reduced sense of touch or sensation)

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 12 people, 26.09%
Breast Cancer Metastatic: 10 people, 21.74%
Neoplasm Malignant (cancer tumour): 8 people, 17.39%
Pain In Jaw: 7 people, 15.22%
Pain: 7 people, 15.22%
Depression: 7 people, 15.22%
Breast Cancer Female: 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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