Levonorgestrel and Naproxen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levonorgestrel (levonorgestrel) and Naproxen (naproxen). Common drug interactions include dactylitis among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Levonorgestrel and Naproxen. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Levonorgestrel?

Levonorgestrel has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 4,186 Levonorgestrel users. Check the latest studies of Levonorgestrel.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,032 Naproxen users. Check the latest studies of Naproxen.

On Jul, 26, 2026

17 people who take Levonorgestrel and Naproxen together, and have interactions are studied.

Levonorgestrel and Naproxen drug interactions.

What are the common drug interactions of Levonorgestrel and Naproxen, by gender? *:

female:

Dactylitis (dactylitis or sausage digit is inflammation of an entire digit (a finger or toe), and can be painful)
Disease progression
Drug ineffective
Fungal infection
General physical health deterioration (weak health status)
Inflammation
Insomnia (sleeplessness)
Joint ankylosis (a stiffness of a joint due to abnormal adhesion and rigidity of the bones of the joint)
Joint range of motion decreased (disease of joint movement)
Joint stiffness

male:

Death
Fall
Gastric ulcer (stomach ulcer)
Loss of consciousness
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the common drug interactions of Levonorgestrel and Naproxen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain lower
Decreased appetite
Dizziness
Drug hypersensitivity
Headache (pain in head)
Pain in extremity
Pancreatitis (inflammation of pancreas)
Pruritus (severe itching of the skin)
Scar
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood potassium decreased
Chronic kidney disease
Decreased activity
Depression
Emotional distress
Fatigue (feeling of tiredness)
Fear
Food craving

40-49:

n/a

50-59:

Angioedema (rapid swelling of the dermis)
Burning sensation
Throat irritation
Erythema multiforme (a type of hypersensitivity reaction)
Hypersensitivity
Pruritus (severe itching of the skin)
Rash erythematous (redness of the skin)
Temperature intolerance (inability to go in temperature)
Urticaria (rash of round, red welts on the skin that itch intensely)
Cough

60+:

n/a

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 23.53%
Migraine (headache): 4 people, 23.53%
Bone Disorder: 4 people, 23.53%
Infection: 2 people, 11.76%
Renal Cell Carcinoma (a kidney cancer): 1 person, 5.88%
Rapid Eye Movements Sleep Abnormal: 1 person, 5.88%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 5.88%
Partial Lipodystrophy (bodily loss or redistribution of fat tissue): 1 person, 5.88%
Oral Herpes (viral infection of mouth): 1 person, 5.88%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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