Lexapro and Eszopiclone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lexapro (escitalopram oxalate) and Eszopiclone (eszopiclone). Common drug interactions include conjunctivitis among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Lexapro and Eszopiclone. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Lexapro?

Lexapro has active ingredients of escitalopram oxalate. It is often used in depression. eHealthMe is studying from 91,464 Lexapro users. Check the latest studies of Lexapro.

What is Eszopiclone?

Eszopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 4,259 Eszopiclone users. Check the latest studies of Eszopiclone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

73 people who take Lexapro and Eszopiclone together, and have interactions are studied.

Lexapro and Eszopiclone drug interactions.

What are the common drug interactions of Lexapro and Eszopiclone, by gender? *:

female:

Conjunctivitis (pink eye)
Drug administration error
Emotional distress
Fall
Gambling
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Oedema peripheral (superficial swelling)
Periarthritis (inflammation of the external coats of an artery and of the tissues around the artery)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Postmenopausal haemorrhage (post-menopausal bleeding)

male:

Fatigue (feeling of tiredness)
Renal failure (kidney dysfunction)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood pressure increased
Chest injury
Chest pain
Chronic kidney disease
Confusional state
Constipation
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)

What are the common drug interactions of Lexapro and Eszopiclone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Septic shock (shock due to blood infection)

20-29:

n/a

30-39:

Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Bone disorder
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Disability
Fatigue (feeling of tiredness)
Hypertension (high blood pressure)
Muscular weakness (muscle weakness)

40-49:

Dizziness
Nausea (feeling of having an urge to vomit)
Hypotension (abnormally low blood pressure)
Pneumonia
Vomiting
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Alopecia (absence of hair from areas of the body)
Hair colour changes
Hair disorder
Renal failure (kidney dysfunction)

50-59:

Fibrin d dimer increased
Fracture displacement
Gingival bleeding (bleeding gums)
Haemangioma of liver (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in liver)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Injection site cellulitis (injection site inflammation)
Injection site thrombosis (injection site blood clotting)
Malaise (a feeling of general discomfort or uneasiness)
Monoparesis (one limb is very weak, but not completely paralyzed)
Neutropenia (an abnormally low number of neutrophils)

60+:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Acne (skin problems that cause pimples)
Oral mucosal erythema (redness of the mucous membrane of mouth)
Rash macular (small, flat red spots)
Skin lesion
Small intestinal obstruction (blockage in small intestine)
Stomatitis (inflammation of mucous membrane of mouth)
Dyspnoea (difficult or laboured respiration)
Herpes zoster
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 19.18%
Pain: 11 people, 15.07%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 10.96%
Sleep Disorder: 7 people, 9.59%
Stress And Anxiety: 5 people, 6.85%
Primary Myelofibrosis (primary disorder of the bone marrow): 4 people, 5.48%
High Blood Pressure: 4 people, 5.48%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.48%

* Approximation only. Some reports may have incomplete information.

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