Lexapro and Hysingla drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lexapro (escitalopram oxalate) and Hysingla (hydrocodone bitartrate). Common drug interactions include feeding disorder among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Lexapro and Hysingla. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Lexapro?

Lexapro has active ingredients of escitalopram oxalate. It is often used in depression. eHealthMe is studying from 91,464 Lexapro users. Check the latest studies of Lexapro.

What is Hysingla?

Hysingla has active ingredients of hydrocodone bitartrate. eHealthMe is studying from 32,609 Hysingla users. Check the latest studies of Hysingla.



On Jul, 12, 2026

20 people who take Lexapro and Hysingla together, and have interactions are studied.

Lexapro and Hysingla drug interactions.

What are the common drug interactions of Lexapro and Hysingla, by gender? *:

female:

  1. Feeding disorder (when children refuse to eat certain food groups)
  2. Pain
  3. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  4. Drug abuse
  5. Drug dependence
  6. Emotional distress
  7. Gastric disorder (disease of stomach)
  8. Gastric ulcer (stomach ulcer)
  9. Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
  10. Pleurisy (inflammation of the pleurae, which causes pain when breathing)

male:

  1. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  2. Drug dependence

What are the common drug interactions of Lexapro and Hysingla, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Drug dependence

40-49:

n/a

50-59:

  1. Death

60+:

  1. Cardiac failure congestive
  2. Exostosis (formation of new bone on the surface of a bone)
  3. Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
  4. Pleurisy (inflammation of the pleurae, which causes pain when breathing)
  5. Pneumonia
  6. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  7. Balance disorder
  8. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  9. Ear infection
  10. Impaired driving ability

What are the existing conditions these people have? *

  1. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 6 people, 30.00%
  2. Nausea (feeling of having an urge to vomit): 3 people, 15.00%
  3. Headache (pain in head): 3 people, 15.00%
  4. Gastric Ulcer (stomach ulcer): 2 people, 10.00%
  5. Pleurisy (inflammation of the pleurae, which causes pain when breathing): 2 people, 10.00%
  6. Pain: 2 people, 10.00%
  7. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 10.00%
  8. Sleep Disorder: 2 people, 10.00%
  9. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 10.00%
  10. High Blood Cholesterol: 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Lexapro and Hysingla:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lexapro:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Hysingla:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lexapro and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Hysingla and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on escitalopram oxalate and hydrocodone bitartrate (the active ingredients of Lexapro and Hysingla, respectively), and Lexapro and Hysingla (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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