Lexapro and Subutex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lexapro (escitalopram oxalate) and Subutex (buprenorphine hydrochloride). Common drug interactions include dyspepsia among females and somnolence among males.

The phase IV clinical study analyzes what interactions people have when they take Lexapro and Subutex. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Lexapro?

Lexapro has active ingredients of escitalopram oxalate. It is often used in depression. eHealthMe is studying from 91,464 Lexapro users. Check the latest studies of Lexapro.

What is Subutex?

Subutex has active ingredients of buprenorphine hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 8,763 Subutex users. Check the latest studies of Subutex.

On Jul, 13, 2026

75 people who take Lexapro and Subutex together, and have interactions are studied.

What are the common drug interactions of Lexapro and Subutex, by gender? *:

female:

Dyspepsia (indigestion)
Early satiety (feeling full before completing a normal sized meal)
Flatulence (flatus expelled through the anus)
Hepatic cyst
Melaena (the passage of black, tarry stools)
Mitral valve incompetence (inefficient heart valve)
Odynophagia (painful swallowing, in the mouth (oropharynx) or oesophagus)
Cystitis (inflammation of the wall of the bladder)
Urethral stenosis (narrowing of the urethra, may cause decreased urine output)
Urinary tract infection

male:

Somnolence (a state of near-sleep, a strong desire for sleep)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dyspnoea (difficult or laboured respiration)
Ear disorder
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Low birth weight baby
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Myalgia (muscle pain)

What are the common drug interactions of Lexapro and Subutex, by age (0-1 to 60+)? *:

0-1:

Foetal growth restriction (poor growth of a baby while in the mother's womb during pregnancy)
Retroplacental haematoma (blood collection entirely behind the placenta)
Stillbirth (a birth of dead foetus)
Crying
Diarrhoea
Disturbance in attention
Emotional disorder
Fear
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Mania (a state of abnormally elevated or irritable mood)

2-9:

n/a

10-19:

n/a

20-29:

Weight decreased
Abdominal pain
Decreased appetite
Gallbladder disorder
Gallbladder pain
Hypoglycaemia (deficiency of glucose in the bloodstream)
Maternal exposure during pregnancy (use of substance during pregnancy)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Drug exposure during pregnancy
Pregnancy

30-39:

Blood chloride decreased
Blood glucose increased
Drug exposure during pregnancy
Dysuria (painful or difficult urination)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
High density lipoprotein decreased
Hypertension (high blood pressure)
Joint swelling
Oedema peripheral (superficial swelling)
Red cell distribution width increased

40-49:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot)

50-59:

Eye infection
Eye pain
Facial bones fracture (bone fracture of face)
Fall
Femur fracture
Glossitis (infection of tongue with soreness)
Groin pain
Haemolytic anaemia (anaemia due to haemolysis)
Hand fracture
Hyperkeratosis (thickening of the outer layer of the skin)

60+:

Nausea (feeling of having an urge to vomit)
Dyspnoea (difficult or laboured respiration)
Anogenital warts
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)
Asthenia (weakness)
Bone disorder
Bone pain
Breast cancer recurrent
Bruxism (habitual grinding of the teeth, typically during sleep)

What are the existing conditions these people have? *

Drug Dependence: 18 people, 24.00%
Stress And Anxiety: 14 people, 18.67%
Insomnia (sleeplessness): 10 people, 13.33%
Nausea (feeling of having an urge to vomit): 9 people, 12.00%
Breast Cancer: 8 people, 10.67%
High Blood Pressure: 7 people, 9.33%
Quit Smoking: 6 people, 8.00%
Pain: 6 people, 8.00%
Constipation: 5 people, 6.67%
Sleep Disorder: 4 people, 5.33%

* Approximation only. Some reports may have incomplete information.

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