Linzess and Creatine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Linzess (linaclotide) and Creatine (creatine). Common drug interactions include abdominal distension among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Linzess and Creatine. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

What is Creatine?

Creatine has active ingredients of creatine. It is often used in muscle mass. eHealthMe is studying from 1,390 Creatine users. Check the latest studies of Creatine.

On Jul, 16, 2026

22 people who take Linzess and Creatine together, and have interactions are studied.

What are the common drug interactions of Linzess and Creatine, by gender? *:

female:

Abdominal distension
Abdominal pain upper
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Fall
Femur fracture
General symptom
Nausea (feeling of having an urge to vomit)
Osteoporosis (bones weak and more likely to break)
Rash
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)

male:

Pneumonia
Pyrexia (fever)
Blood cholesterol increased
Hepatic enzyme increased
Hypoaesthesia (reduced sense of touch or sensation)
Infection
Malaise (a feeling of general discomfort or uneasiness)
Spinal cord injury
Adverse event
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)

What are the common drug interactions of Linzess and Creatine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)

20-29:

Rash
Urticaria (rash of round, red welts on the skin that itch intensely)

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Abdominal distension
Abdominal pain upper
Pain
Pyrexia (fever)
Sputum increased
Urinary tract infection
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Diarrhoea
Fall
Femur fracture

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 12 people, 54.55%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 27.27%
Combined Immunodeficiency: 6 people, 27.27%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 27.27%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 4 people, 18.18%
Primary Immunodeficiency Syndrome: 3 people, 13.64%
Inflammatory Bowel Disease: 2 people, 9.09%
Immunodeficiency: 2 people, 9.09%
Drowsiness: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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