Linzess and Zithromax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Linzess (linaclotide) and Zithromax (azithromycin). Common drug interactions include cerebral palsy among females and muscle spasms among males.

The phase IV clinical study analyzes what interactions people have when they take Linzess and Zithromax. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

What is Zithromax?

Zithromax has active ingredients of azithromycin. It is often used in sinusitis. eHealthMe is studying from 35,525 Zithromax users. Check the latest studies of Zithromax.

On Jul, 15, 2026

54 people who take Linzess and Zithromax together, and have interactions are studied.

Linzess and Zithromax drug interactions.

What are the common drug interactions of Linzess and Zithromax, by gender? *:

female:

Cerebral palsy
Chest discomfort
Chest injury
Coma (state of unconsciousness lasting more than six hours)
Contusion (a type of hematoma of tissue in which capillaries)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Coronary artery stenosis (narrowing of coronary artery)
Coronary ostial stenosis (narrowing of the mouths of the coronary arteries)
Cough
Dental caries

male:

Muscle spasms (muscle contraction)
Drug ineffective
Nephrolithiasis (calculi in the kidneys)
Palpitations (feelings or sensations that your heart is pounding or racing)
Stiff person syndrome
Chronic kidney disease
Decreased appetite
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nasopharyngitis (inflammation of the nasopharynx)

What are the common drug interactions of Linzess and Zithromax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

20-29:

Back pain
Cat scratch disease (bacterial infection by cat scratch)
Coma (state of unconsciousness lasting more than six hours)
Cyclic vomiting syndrome (prolonged episodes of severe nausea, vomiting)
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)
Hyposmia (impairment of the sense of smell)
Impaired gastric emptying
Increased appetite
Muscle spasms (muscle contraction)

30-39:

Actinomycosis (infection that causes sores, or abscesses)
Acute respiratory distress syndrome
Cardiac disorder
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Coma (state of unconsciousness lasting more than six hours)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Headache (pain in head)
Hyperglycaemia (high blood sugar)
Hypervolaemia (abnormally increased volume of blood)
Hypotension (abnormally low blood pressure)

40-49:

Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Arthralgia (joint pain)
Back pain
Blood pressure decreased
Bone density decreased
Bone loss
Cardiac discomfort
Cardiac flutter (abnormal heart rhythm)
Cerebral palsy
Chest injury

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Bipolar disorder (mood disorder)
Breast cancer
Depression
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Lung neoplasm malignant (cancer tumour of lung)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)

60+:

Chronic kidney disease
Chest pain
Rash erythematous (redness of the skin)
Abdominal pain
Abdominal pain upper
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)
Atrioventricular block (heart block)
Back pain
Balance disorder

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 18 people, 33.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 18 people, 33.33%
Pain: 12 people, 22.22%
Stress And Anxiety: 12 people, 22.22%
Infection: 11 people, 20.37%
High Blood Cholesterol: 9 people, 16.67%
Irritable Bowel Syndrome: 8 people, 14.81%
High Blood Pressure: 8 people, 14.81%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 7 people, 12.96%
Depression: 7 people, 12.96%

* Approximation only. Some reports may have incomplete information.

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