Locoid and Simvastatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Locoid (hydrocortisone butyrate) and Simvastatin (simvastatin). Common drug interactions include anaemia among females and obsessive-compulsive disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Locoid and Simvastatin. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Locoid?

Locoid has active ingredients of hydrocortisone butyrate. eHealthMe is studying from 1,996 Locoid users. Check the latest studies of Locoid.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

On Aug, 05, 2026

46 people who take Locoid and Simvastatin together, and have interactions are studied.

Locoid and Simvastatin drug interactions.

What are the common drug interactions of Locoid and Simvastatin, by gender? *:

female:

Anaemia (lack of blood)
Anal abscess
Arrhythmia (irregular heartbeat)
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood creatinine increased
Bone marrow failure
Cardiac failure
Death
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)

male:

Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Rectal haemorrhage (bleeding from anus)
Lentigo (a small pigmented spot on the skin with a clearly-defined edge, surrounded by normal-appearing skin)
Lumbar radiculopathy (radicular pain in the low back and legs)
Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))
Neuropathy peripheral (surface nerve damage)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Polyp
Telangiectasia (small dilated blood vessels near the surface of the skin)
Alanine aminotransferase increased

What are the common drug interactions of Locoid and Simvastatin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Lymphocyte count decreased
Myalgia (muscle pain)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Neutrophilia
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
Stomatitis (inflammation of mucous membrane of mouth)
Thyroiditis subacute (inflammation of thyroid gland less severe and less durational)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase decreased

30-39:

n/a

40-49:

Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Anaemia (lack of blood)
Arrhythmia (irregular heartbeat)
Blood creatinine increased
Cardiac failure
Diarrhoea
Diplopia (double vision)
Erythema (redness of the skin)
Glossitis (infection of tongue with soreness)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

50-59:

Cardiac arrest
Dry skin
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Pruritus (severe itching of the skin)

60+:

Death
Joint swelling
Ketoacidosis (high concentrations of ketone bodies in blood)
Non-cardiac chest pain
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Colitis (inflammation of colon)
Anal abscess
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Bone marrow failure

What are the existing conditions these people have? *

High Blood Pressure: 11 people, 23.91%
Constipation: 7 people, 15.22%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 7 people, 15.22%
Type 2 Diabetes: 6 people, 13.04%
Stress And Anxiety: 6 people, 13.04%
Nausea And Vomiting: 6 people, 13.04%
Depression: 4 people, 8.70%
Diabetes: 4 people, 8.70%
Indigestion: 4 people, 8.70%
Pain: 4 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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