Lonsurf and Diazepam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lonsurf (tipiracil hydrochloride; trifluridine) and Diazepam (diazepam). Common drug interactions include fatigue among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Lonsurf and Diazepam. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Lonsurf?

Lonsurf has active ingredients of tipiracil hydrochloride; trifluridine. eHealthMe is studying from 10,077 Lonsurf users. Check the latest studies of Lonsurf.

What is Diazepam?

Diazepam has active ingredients of diazepam. It is often used in stress and anxiety. eHealthMe is studying from 108,384 Diazepam users. Check the latest studies of Diazepam.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

35 people who take Lonsurf and Diazepam together, and have interactions are studied.

What are the common drug interactions of Lonsurf and Diazepam, by gender? *:

female:

Fatigue (feeling of tiredness)
Stomatitis (inflammation of mucous membrane of mouth)
Nausea (feeling of having an urge to vomit)
Death
Abdominal discomfort
Diarrhoea
Hyperkalaemia (damage to or disease of the kidney)
Hypertension (high blood pressure)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Neuropathy peripheral (surface nerve damage)

male:

Asthenia (weakness)
Weight decreased
Malaise (a feeling of general discomfort or uneasiness)
Pain
Pyrexia (fever)
White blood cell count decreased
Abdominal discomfort
Abdominal pain
Acute myocardial infarction (acute heart attack)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the common drug interactions of Lonsurf and Diazepam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Malignant neoplasm progression (cancer tumour came back)

40-49:

Abdominal discomfort
Death
Fatigue (feeling of tiredness)
Hyperkalaemia (damage to or disease of the kidney)
Hypertension (high blood pressure)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Neuropathy peripheral (surface nerve damage)
Stomatitis (inflammation of mucous membrane of mouth)
Disease progression
Carcinoembryonic antigen increased

50-59:

Neutropenia (an abnormally low number of neutrophils)
Upper respiratory tract infection
Asthenia (weakness)
Fall
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Hypotension (abnormally low blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Mouth ulceration (mouth ulcers)

60+:

Fatigue (feeling of tiredness)
Diarrhoea
Alopecia (absence of hair from areas of the body)
Gait disturbance
Stomatitis (inflammation of mucous membrane of mouth)
Urinary tract infection
Abdominal pain
Anaemia (lack of blood)
Death
Disease progression

What are the existing conditions these people have? *

Colon Cancer: 12 people, 34.29%
Rectal Cancer (cancer of rectum): 5 people, 14.29%
Rectosigmoid Cancer (cancer that originates in the rectum and sigmoid colon): 4 people, 11.43%
Pain: 4 people, 11.43%
Quit Smoking: 3 people, 8.57%
Neuropathy Peripheral (surface nerve damage): 3 people, 8.57%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 3 people, 8.57%
Chronic Respiratory Disease: 3 people, 8.57%
Sleep Disorder: 2 people, 5.71%
Neoplasm Malignant (cancer tumour): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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