Lopid and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lopid (gemfibrozil) and Diphen (diphenhydramine hydrochloride). Common drug interactions include dysphagia among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Lopid and Diphen. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Lopid?

Lopid has active ingredients of gemfibrozil. It is often used in high blood cholesterol. eHealthMe is studying from 9,700 Lopid users. Check the latest studies of Lopid.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

On Jul, 19, 2026

56 people who take Lopid and Diphen together, and have interactions are studied.

What are the common drug interactions of Lopid and Diphen, by gender? *:

female:

Dysphagia (a condition in which swallowing is difficult or painful)
Sinusitis (inflammation of sinus)
Contusion (a type of hematoma of tissue in which capillaries)
Dehydration (dryness resulting from the removal of water)
Dizziness
Fall
Decreased appetite
Influenza
Staphylococcal infection (an infection with staphylococcus bacteria)
Infusion site pain

male:

Pneumonia
Pulmonary mass
Gait disturbance
Injury
Pain
Anxiety
Arthralgia (joint pain)
Depression
Iron deficiency
Pulmonary function test decreased

What are the common drug interactions of Lopid and Diphen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Disability
Fear
Injury
Multi-organ failure (multisystem organ failure)
Pain
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

50-59:

Pulmonary mass
Abdominal hernia
Abdominal pain
Acidosis (build-up of carbon dioxide in the blood)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Ankle fracture
Aortic valve incompetence
Arteriosclerosis (thickening and hardening of arteries)

60+:

Weight decreased
Dysphagia (a condition in which swallowing is difficult or painful)
Influenza
Infusion site pain
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)
Urinary tract infection
Fatigue (feeling of tiredness)
Pneumonia
Gait disturbance

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 13 people, 23.21%
High Blood Pressure: 11 people, 19.64%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 6 people, 10.71%
Multifocal Motor Neuropathy (a progressively worsening condition where muscles in the extremities gradually weaken): 6 people, 10.71%
Stress And Anxiety: 5 people, 8.93%
Dry Eyes (lack of adequate tears): 5 people, 8.93%
Diabetes: 5 people, 8.93%
Hiv Infection: 4 people, 7.14%
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 4 people, 7.14%
Fungal Skin Infection: 4 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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