Lorazepam and Fiorinal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lorazepam (lorazepam) and Fiorinal (aspirin; butalbital; caffeine). Common drug interactions include bedridden among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Lorazepam and Fiorinal. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Lorazepam?

Lorazepam has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,639 Lorazepam users. Check the latest studies of Lorazepam.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

On Jul, 12, 2026

87 people who take Lorazepam and Fiorinal together, and have interactions are studied.

Lorazepam and Fiorinal drug interactions.

What are the common drug interactions of Lorazepam and Fiorinal, by gender? *:

female:

Bedridden
Cough
Crying
Eye swelling
Fibromyalgia (a long-term condition which causes pain all over the body)
Hypotension (abnormally low blood pressure)
Joint swelling
Lacrimation increased
Ankylosing spondylitis (type of arthritis affecting the spine)
Arthropathy

male:

Depression
Completed suicide (act of taking one's own life)
Pathological gambling
Suicidal ideation
Weight increased
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Aggression
Blood calcium decreased
Blood creatinine decreased
Blood oestrogen increased

What are the common drug interactions of Lorazepam and Fiorinal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Attention deficit/hyperactivity disorder
Blood cholesterol increased
Burning sensation
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dehydration (dryness resulting from the removal of water)
Depression
Drug addiction
Nausea (feeling of having an urge to vomit)
Oesophageal spasm (contraction of oesophagus)

30-39:

n/a

40-49:

Drug addiction
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Suicide attempt

50-59:

Lacrimation increased
Neuropathy peripheral (surface nerve damage)
Vision blurred
Fall
Chronic kidney disease
Diarrhoea
Initial insomnia (feeling of inadequate or poor-quality sleep)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)

60+:

Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Diarrhoea
Fatigue (feeling of tiredness)
Vomiting
Abdominal pain
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood creatinine increased

What are the existing conditions these people have? *

Insomnia (sleeplessness): 20 people, 22.99%
High Blood Pressure: 13 people, 14.94%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 14.94%
Pain: 11 people, 12.64%
Depression: 9 people, 10.34%
Urinary Tract Infection: 7 people, 8.05%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 7 people, 8.05%
Gastrointestinal Motility Disorder (abnormal intestinal contractions): 6 people, 6.90%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 6.90%
Sleep Disorder: 5 people, 5.75%

* Approximation only. Some reports may have incomplete information.

Do you take Lorazepam and Fiorinal?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously