Lorazepam and Macitentan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lorazepam (lorazepam) and Macitentan (macitentan). Common drug interactions include haematoma among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Lorazepam and Macitentan. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Lorazepam?

Lorazepam has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,639 Lorazepam users. Check the latest studies of Lorazepam.

What is Macitentan?

Macitentan has active ingredients of macitentan. eHealthMe is studying from 7,371 Macitentan users. Check the latest studies of Macitentan.

On Jul, 09, 2026

46 people who take Lorazepam and Macitentan together, and have interactions are studied.

Lorazepam and Macitentan drug interactions.

What are the common drug interactions of Lorazepam and Macitentan, by gender? *:

female:

Haematoma (collection of blood outside the blood vessels)
Hand fracture
Overdose
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Death
Headache (pain in head)
Abdominal pain upper
Drug ineffective
Malaise (a feeling of general discomfort or uneasiness)
Bone pain

male:

Diarrhoea
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Fall
Hypoaesthesia (reduced sense of touch or sensation)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Lung transplant
Hypotension (abnormally low blood pressure)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

What are the common drug interactions of Lorazepam and Macitentan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Overdose
Drug ineffective

40-49:

Bone pain
Diarrhoea
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Overdose
Hospitalisation
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Pain of skin
Pneumonia
Rash papular (redness with papule)

50-59:

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Hypoxia (low oxygen in tissues)
Increased appetite
Infusion site pain
Joint stiffness
Lung disorder (lung disease)
Lymphocyte count decreased
Multiple fractures
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Oral herpes (viral infection of mouth)

60+:

Death
Abdominal pain upper
Cardiac disorder
Drug ineffective
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Headache (pain in head)
Myalgia (muscle pain)
Oxygen saturation decreased

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 34 people, 73.91%
Insomnia (sleeplessness): 15 people, 32.61%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 9 people, 19.57%
High Blood Pressure: 8 people, 17.39%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 15.22%
High Blood Cholesterol: 6 people, 13.04%
Pain: 6 people, 13.04%
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection): 5 people, 10.87%
Cardiac Failure: 5 people, 10.87%
Fear: 5 people, 10.87%

* Approximation only. Some reports may have incomplete information.

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