Lorazepam and Simbrinza drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lorazepam (lorazepam) and Simbrinza (brimonidine tartrate; brinzolamide). Common drug interactions include drug ineffective among females and vertigo among males.

The phase IV clinical study analyzes what interactions people have when they take Lorazepam and Simbrinza. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Lorazepam?

Lorazepam has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,639 Lorazepam users. Check the latest studies of Lorazepam.

What is Simbrinza?

Simbrinza has active ingredients of brimonidine tartrate; brinzolamide. It is often used in glaucoma. eHealthMe is studying from 4,543 Simbrinza users. Check the latest studies of Simbrinza.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

22 people who take Lorazepam and Simbrinza together, and have interactions are studied.

Lorazepam and Simbrinza drug interactions.

What are the common drug interactions of Lorazepam and Simbrinza, by gender? *:

female:

Drug ineffective
Delusion (a false belief or opinion)
Dementia (madness)
Freezing phenomenon
Hallucination (an experience involving the perception of something not present)
Intentional self-injury
Parkinson's disease
Cardiac arrest
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chronic kidney disease

male:

Vertigo
Abdominal discomfort
Cough
Dental plaque (film of mucus and bacteria deposited on the teeth that encourages the development of dental caries)
Dizziness
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Dysstasia (difficulty in standing)
Epistaxis (bleed from the nose)
Fear

What are the common drug interactions of Lorazepam and Simbrinza, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Oropharyngeal plaque (hard deposit on oropharynx)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pyrexia (fever)
Rectal haemorrhage (bleeding from anus)
Reiter's syndrome (a type of reactive arthritis, it happens as a reaction to a bacterial infection)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Road traffic accident
Throat irritation
Urine output decreased

60+:

Vertigo
Abdominal discomfort
Arthralgia (joint pain)
Balance disorder
Bladder pain
Blood urine present
Cardiac arrest
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chronic kidney disease
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)

What are the existing conditions these people have? *

Pain: 5 people, 22.73%
Diarrhea: 4 people, 18.18%
Constipation: 4 people, 18.18%
Sleep Disorder: 3 people, 13.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.64%
Cholangiocarcinoma (a cancer that forms glands or secretes significant amounts of mucins): 3 people, 13.64%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 9.09%
Parkinson's Disease: 2 people, 9.09%
Oral Herpes (viral infection of mouth): 2 people, 9.09%
Intraocular Pressure Increased: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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