Lorazepam and Trikafta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lorazepam (lorazepam) and Trikafta (elexacaftor, ivacaftor, tezacaftor; ivacaftor). Common drug interactions include paraesthesia among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Lorazepam and Trikafta. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.

What is Lorazepam?

Lorazepam has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,639 Lorazepam users. Check the latest studies of Lorazepam.

What is Trikafta?

Trikafta has active ingredients of elexacaftor, ivacaftor, tezacaftor; ivacaftor. eHealthMe is studying from 11,852 Trikafta users. Check the latest studies of Trikafta.

On Jul, 13, 2026

97 people who take Lorazepam and Trikafta together, and have interactions are studied.

Lorazepam and Trikafta drug interactions.

What are the common drug interactions of Lorazepam and Trikafta, by gender? *:

female:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pelvic pain
Postmenopausal haemorrhage (post-menopausal bleeding)
Rash papular (redness with papule)
Rash pruritic (redness with itching)
Respiratory tract congestion (blockage on respiratory system)
Somnolence (a state of near-sleep, a strong desire for sleep)
Syncope (loss of consciousness with an inability to maintain postural tone)
Abdominal discomfort
Burning sensation

male:

Vomiting
Adjustment disorder
Suicidal ideation
Abdominal distension
Abdominal pain
Alanine aminotransferase increased
Alcohol withdrawal syndrome
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

What are the common drug interactions of Lorazepam and Trikafta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Sputum increased
Vomiting
Nasopharyngitis (inflammation of the nasopharynx)
Nephrolithiasis (calculi in the kidneys)
Pulmonary function test decreased

20-29:

Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Depression
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Mood altered (changes in mood)
Peripheral swelling
Suicidal ideation
Abdominal discomfort
Abdominal pain
Cystic fibrosis (disease of the secretary glands)
Diarrhoea

30-39:

Maternal exposure during pregnancy (use of substance during pregnancy)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Pneumonia
Premature menopause
Surgery
Weight increased
Cystic fibrosis (disease of the secretary glands)
Infection
Pre-eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman)

40-49:

Blood triglycerides increased
Xanthelasma (yellow flat plaques over the upper or lower eyelids)
Abdominal distension
Abdominal pain
Constipation
Increased appetite
Weight increased
Depression
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Blood follicle stimulating hormone increased

50-59:

Finger deformity (a deformed position of the finger)
Inflammatory marker increased
Depressed mood
Memory impairment
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pulmonary function test decreased
Dyspnoea (difficult or laboured respiration)
Abnormal dreams
Blood glucose decreased
Confusional state

60+:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Drug ineffective
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Nausea (feeling of having an urge to vomit)
Pneumonia
Respiratory tract congestion (blockage on respiratory system)

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 90 people, 92.78%
Cystic Fibrosis Lung (fibrosis with cyst in the lung): 10 people, 10.31%
Pain: 7 people, 7.22%
Type 2 Diabetes: 6 people, 6.19%
Indigestion: 6 people, 6.19%
Constipation: 6 people, 6.19%
Insomnia (sleeplessness): 5 people, 5.15%
Fever: 5 people, 5.15%
Depression: 5 people, 5.15%
Asthma: 5 people, 5.15%

* Approximation only. Some reports may have incomplete information.

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