Lortab and Mercaptopurine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lortab (acetaminophen; hydrocodone bitartrate) and Mercaptopurine (mercaptopurine). Common drug interactions include rectal haemorrhage among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Lortab and Mercaptopurine. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

What is Mercaptopurine?

Mercaptopurine has active ingredients of mercaptopurine. It is often used in crohn's disease. eHealthMe is studying from 23,013 Mercaptopurine users. Check the latest studies of Mercaptopurine.

On Aug, 05, 2026

34 people who take Lortab and Mercaptopurine together, and have interactions are studied.

Lortab and Mercaptopurine drug interactions.

What are the common drug interactions of Lortab and Mercaptopurine, by gender? *:

female:

Rectal haemorrhage (bleeding from anus)
Screaming (a long loud piercing cry)
Sinusitis (inflammation of sinus)
Skin graft failure (skin transplant failed)
Swelling
Tongue ulceration (ulcers on tongue)
Tonsillitis (inflammation of tonsil)
Tooth erosion (dissolving teeth)
Tooth fracture
Tooth infection

male:

Vomiting
Abdominal distension
Ear pain
Headache (pain in head)
Tinnitus (a ringing in the ears)
Vision blurred
Dysphonia (speech disorder attributable to a disorder of phonation)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Glossodynia (a burning or painful sensation in the tongue)
Premature baby

What are the common drug interactions of Lortab and Mercaptopurine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arthralgia (joint pain)
Arthropathy
Bone infarction (ischemic death of the cellular elements of the bone and marrow)
Bone pain
Decreased appetite
Gait disturbance
Headache (pain in head)
Impaired work ability
Joint destruction (joint damage)
Joint effusion (presence of extra fluid in joint covering)

20-29:

Abdominal pain
Deafness
Ear pain
Headache (pain in head)
Pulmonary embolism (blockage of the main artery of the lung)
Tinnitus (a ringing in the ears)
Vision blurred
Catheter related complication
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

30-39:

Abdominal pain
Acne (skin problems that cause pimples)
Anal fistula
Anal stenosis (narrowing of the anal sphincter and opening)
Crying
Diarrhoea
Fatigue (feeling of tiredness)
Gait disturbance
Injection site bruising
Injection site pain

40-49:

Arthralgia (joint pain)
Pain in extremity
Breast haematoma (blood-filled swelling in the breast)
Breast mass
Urticaria (rash of round, red welts on the skin that itch intensely)
Abdominal pain upper
Fatigue (feeling of tiredness)
Gait disturbance
Swelling
Tooth erosion (dissolving teeth)

50-59:

Abdominal distension
Clostridial infection (infectious conditions by clostridium bacteria)
Device related infection
Nausea (feeling of having an urge to vomit)
Vomiting
Blood pressure increased
Constipation
Fistula (an abnormal connection or passageway between two)
Scar
Injection site haemorrhage (bleeding from injection site)

60+:

Dysphonia (speech disorder attributable to a disorder of phonation)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Drug ineffective
Ear infection
Oropharyngeal pain
Sinusitis (inflammation of sinus)
Tonsillitis (inflammation of tonsil)
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Glossodynia (a burning or painful sensation in the tongue)
Premature baby

What are the existing conditions these people have? *

Depression: 10 people, 29.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 14.71%
Neck Pain: 5 people, 14.71%
Nausea (feeling of having an urge to vomit): 5 people, 14.71%
Skin Disorder (skin disease): 5 people, 14.71%
Stress And Anxiety: 4 people, 11.76%
Intervertebral Disc Protrusion (spinal disc protrusion): 3 people, 8.82%
High Blood Pressure: 3 people, 8.82%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 2 people, 5.88%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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