Loryna and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Loryna (drospirenone; ethinyl estradiol) and Zoloft (sertraline hydrochloride). Common drug interactions include ankylosing spondylitis among females.

The phase IV clinical study analyzes what interactions people have when they take Loryna and Zoloft. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Loryna?

Loryna has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 388 Loryna users. Check the latest studies of Loryna.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,801 Zoloft users. Check the latest studies of Zoloft.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

19 people who take Loryna and Zoloft together, and have interactions are studied.

What are the common drug interactions of Loryna and Zoloft, by gender? *:

female:

Ankylosing spondylitis (type of arthritis affecting the spine)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Chest discomfort
Dizziness
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypomania (a mild form of mania, marked by elation and hyperactivity)
Impulse-control disorder
Lactose intolerance (inability to digest lactose)
Muscle rigidity (muscle stiffness)

male:

n/a

What are the common drug interactions of Loryna and Zoloft, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pruritus (severe itching of the skin)
Skin reaction
Dizziness
Headache (pain in head)
Hypomania (a mild form of mania, marked by elation and hyperactivity)
Impulse-control disorder
Muscle rigidity (muscle stiffness)
Night sweats (sweating in night)
Pain in jaw
Contusion (a type of hematoma of tissue in which capillaries)

20-29:

Ankylosing spondylitis (type of arthritis affecting the spine)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Osteomalacia (softening of the bones due to a lack of vitamin d)
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Vitamin d deficiency
Back pain
Sinusitis (inflammation of sinus)
Urinary tract infection

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 52.63%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 4 people, 21.05%
Respiratory Disorder (respiratory disease): 3 people, 15.79%
Drowsiness: 3 people, 15.79%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 15.79%
Immune System Disorder: 2 people, 10.53%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 5.26%
Stress And Anxiety: 1 person, 5.26%
Social Phobia (fear to go in social): 1 person, 5.26%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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