Losartan and Irinotecan hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Losartan (losartan potassium) and Irinotecan hydrochloride (irinotecan hydrochloride). Common drug interactions include leukopenia among females and atypical pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Losartan and Irinotecan hydrochloride. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Losartan?

Losartan has active ingredients of losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 177,686 Losartan users. Check the latest studies of Losartan.

What is Irinotecan hydrochloride?

Irinotecan hydrochloride has active ingredients of irinotecan hydrochloride. It is often used in cancer. eHealthMe is studying from 7,166 Irinotecan hydrochloride users. Check the latest studies of Irinotecan hydrochloride.

On Jul, 10, 2026

25 people who take Losartan and Irinotecan hydrochloride together, and have interactions are studied.

Losartan and Irinotecan hydrochloride drug interactions.

What are the common drug interactions of Losartan and Irinotecan Hydrochloride, by gender? *:

female:

Leukopenia (less number of white blood cells in blood)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Nausea (feeling of having an urge to vomit)
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)
Pyrexia (fever)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)

male:

Atypical pneumonia (acute respiratory disease marked by high fever and coughing)
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Muscular weakness (muscle weakness)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Pulmonary artery thrombosis (blockage of the main artery of the lung)
Syncope (loss of consciousness with an inability to maintain postural tone)
Cholinergic syndrome (symptoms of increased cholinergic stimulation)
Gastrointestinal toxicity (damage to digestive tract by any substance)
Haematotoxicity (toxins that destroy red blood cells)
Hypertransaminasaemia

What are the common drug interactions of Losartan and Irinotecan Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cholinergic syndrome (symptoms of increased cholinergic stimulation)
Gastrointestinal toxicity (damage to digestive tract by any substance)
Haematotoxicity (toxins that destroy red blood cells)
Hypertransaminasaemia
Thrombocytopenia (decrease of platelets in blood)

50-59:

Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Limb discomfort (discomfort in leg)
Muscle twitching
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Swollen tongue (swelling of tongue)
Vision blurred
Malaise (a feeling of general discomfort or uneasiness)
Nail toxicity (nail damaged due to toxin)

60+:

Atypical pneumonia (acute respiratory disease marked by high fever and coughing)
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)
Pyrexia (fever)
Thrombocytopenia (decrease of platelets in blood)
Vomiting
Fatigue (feeling of tiredness)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Leukocytosis (increased white blood cells)
Anaemia (lack of blood)

What are the existing conditions these people have? *

Pancreatic Carcinoma (pancreatic cancer): 7 people, 28.00%
Rectal Cancer (cancer of rectum): 4 people, 16.00%
Nausea And Vomiting: 4 people, 16.00%
Colon Cancer: 4 people, 16.00%
Adenocarcinoma Pancreas (cancer of pancreas): 4 people, 16.00%
Pain: 2 people, 8.00%
Nausea (feeling of having an urge to vomit): 2 people, 8.00%
Constipation: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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