Lyrica and Apokyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lyrica (pregabalin) and Apokyn (apomorphine hydrochloride). Common drug interactions include somnolence among females and somnolence among males.

The phase IV clinical study analyzes what interactions people have when they take Lyrica and Apokyn. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Lyrica?

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 261,646 Lyrica users. Check the latest studies of Lyrica.

What is Apokyn?

Apokyn has active ingredients of apomorphine hydrochloride. eHealthMe is studying from 5,284 Apokyn users. Check the latest studies of Apokyn.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

53 people who take Lyrica and Apokyn together, and have interactions are studied.

What are the common drug interactions of Lyrica and Apokyn, by gender? *:

female:

Somnolence (a state of near-sleep, a strong desire for sleep)
Nausea (feeling of having an urge to vomit)
Yawning (simultaneous inhalation of air and stretching of the eardrums, followed by exhalation of breath)
Fall
Blood pressure decreased
Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Arthralgia (joint pain)
Back injury
Back pain

male:

Somnolence (a state of near-sleep, a strong desire for sleep)
Nausea (feeling of having an urge to vomit)
Confusional state
Joint stiffness
Joint swelling
Peripheral swelling
Asthenia (weakness)
Dyskinesia (abnormality or impairment of voluntary movement)
Gait disturbance
Hallucination (an experience involving the perception of something not present)

What are the common drug interactions of Lyrica and Apokyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Somnolence (a state of near-sleep, a strong desire for sleep)
Nausea (feeling of having an urge to vomit)
Arthralgia (joint pain)
Back pain
Joint stiffness
Joint swelling
Peripheral swelling
Aggression
Blood pressure decreased
Gait disturbance

What are the existing conditions these people have? *

Parkinson's Disease: 48 people, 90.57%
Sleep Disorder: 3 people, 5.66%
Depression: 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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