Lysteda and Ibu drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lysteda (tranexamic acid) and Ibu (ibuprofen). Common drug interactions include blood creatinine decreased among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Lysteda and Ibu. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Lysteda?

Lysteda has active ingredients of tranexamic acid. It is often used in menstrual periods - heavy, prolonged, or irregular. eHealthMe is studying from 289 Lysteda users. Check the latest studies of Lysteda.

What is Ibu?

Ibu has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 246,531 Ibu users. Check the latest studies of Ibu.



On Jul, 26, 2026

14 people who take Lysteda and Ibu together, and have interactions are studied.

Lysteda and Ibu drug interactions.

What are the common drug interactions of Lysteda and Ibu, by gender? *:

female:

  1. Blood creatinine decreased
  2. Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
  3. Mood altered (changes in mood)
  4. Nausea (feeling of having an urge to vomit)
  5. Oral herpes (viral infection of mouth)
  6. Partial seizures (seizures which affect only a part of the brain at onset)
  7. Stress
  8. Suppressed lactation
  9. Abdominal pain
  10. Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)

male:

  1. Death

What are the common drug interactions of Lysteda and Ibu, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Contusion (a type of hematoma of tissue in which capillaries)
  2. Partial seizures (seizures which affect only a part of the brain at onset)
  3. Seizure (abnormal excessive or synchronous neuronal activity in the brain)

30-39:

  1. Abdominal pain
  2. Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
  3. Diarrhoea
  4. Drug ineffective
  5. Fall
  6. Fatigue (feeling of tiredness)
  7. General physical health deterioration (weak health status)
  8. Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
  9. Immunodeficiency
  10. Incontinence (lack of moderation or self-control)

40-49:

  1. Hysterectomy

50-59:

  1. Hereditary angioedema (recurrent episodes of severe swelling)

60+:

n/a

What are the existing conditions these people have? *

  1. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 21.43%
  2. Neuralgia (pain in one or more nerves): 3 people, 21.43%
  3. Muscle Spasms (muscle contraction): 3 people, 21.43%
  4. Headache (pain in head): 3 people, 21.43%
  5. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 14.29%
  6. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 14.29%
  7. Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 2 people, 14.29%
  8. Nausea (feeling of having an urge to vomit): 2 people, 14.29%
  9. Heavy Or Prolong Menstrual Bleeding: 2 people, 14.29%
  10. Hereditary Angioedema (recurrent episodes of severe swelling): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Lysteda and Ibu?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Lysteda and Ibu:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lysteda:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ibu:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lysteda and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ibu and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on tranexamic acid and ibuprofen (the active ingredients of Lysteda and Ibu, respectively), and Lysteda and Ibu (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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