Macrobid and Skelaxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) and Skelaxin (metaxalone). Common drug interactions include speech disorder among females and scar among males.

The phase IV clinical study analyzes what interactions people have when they take Macrobid and Skelaxin. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Skelaxin?

Skelaxin has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 9,706 Skelaxin users. Check the latest studies of Skelaxin.

On Jul, 12, 2026

87 people who take Macrobid and Skelaxin together, and have interactions are studied.

Macrobid and Skelaxin drug interactions.

What are the common drug interactions of Macrobid and Skelaxin, by gender? *:

female:

Speech disorder
Dry mouth
Dyspnoea (difficult or laboured respiration)
Oropharyngeal pain
Hypertension (high blood pressure)
Pain
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Stomatitis (inflammation of mucous membrane of mouth)
Cough
Dysphonia (speech disorder attributable to a disorder of phonation)

male:

Scar
Acute sinusitis
Candidiasis (candidiasis or thrush is a fungal infection)
Cellulitis (infection under the skin)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Decreased appetite
Device related infection

What are the common drug interactions of Macrobid and Skelaxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Scar
Acute sinusitis
Anaemia (lack of blood)
Angiopathy (generic term for a disease of the blood vessels)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Arthropathy
Bone disorder
Bone loss

10-19:

n/a

20-29:

Pulmonary embolism (blockage of the main artery of the lung)

30-39:

Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hyperglycaemia (high blood sugar)
Insomnia (sleeplessness)
Sleep disorder
Type 2 diabetes mellitus
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug hypersensitivity
Erythema multiforme (a type of hypersensitivity reaction)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Neck pain

40-49:

Headache (pain in head)
Chest pain
Speech disorder
Neck pain
Vision blurred
Abdominal distension
Hypoaesthesia (reduced sense of touch or sensation)
Narcolepsy (brain's inability to regulate sleep-wake cycles normally)
Anxiety
Intermenstrual bleeding

50-59:

Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Contusion (a type of hematoma of tissue in which capillaries)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Joint effusion (presence of extra fluid in joint covering)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Panic reaction
Psychogenic pain disorder
Social avoidant behaviour (avoiding social connection a personality disorder)
Substance-induced psychotic disorder
Abdominal pain

60+:

Diarrhoea
Anxiety
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Aortic arteriosclerosis (hardening of the aortic arteries)
Discomfort
Dysphonia (speech disorder attributable to a disorder of phonation)
Emotional distress
Feeling jittery
Fractured sacrum
Gingival bleeding (bleeding gums)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 24 people, 27.59%
Multiple Myeloma (cancer of the plasma cells): 14 people, 16.09%
Depression: 11 people, 12.64%

* Approximation only. Some reports may have incomplete information.

Do you take Macrobid and Skelaxin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously