Malarone and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Malarone (atovaquone; proguanil hydrochloride) and Profen (ibuprofen). Common drug interactions include bone marrow failure among females and erythema multiforme among males.

The phase IV clinical study analyzes what interactions people have when they take Malarone and Profen. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Malarone?

Malarone has active ingredients of atovaquone; proguanil hydrochloride. It is often used in malaria. eHealthMe is studying from 3,098 Malarone users. Check the latest studies of Malarone.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,312 Profen users. Check the latest studies of Profen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

18 people who take Malarone and Profen together, and have interactions are studied.

What are the common drug interactions of Malarone and Profen, by gender? *:

female:

Bone marrow failure
Chemical burn of skin
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Drug hypersensitivity
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Escherichia infection (bacterial infection by escherichia coli)
Face oedema (swelling of face)
Hepatocellular damage (liver damage)
Hypersomnia (excessive daytime sleepiness (eds))

male:

Erythema multiforme (a type of hypersensitivity reaction)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Oedema peripheral (superficial swelling)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Vision blurred

What are the common drug interactions of Malarone and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abnormal dreams
Angioedema (rapid swelling of the dermis)
Dysphonia (speech disorder attributable to a disorder of phonation)
Hypersomnia (excessive daytime sleepiness (eds))
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary infarction (death of a small area of lung)
Respiration (transport of oxygen from the outside air to the cells within tissues)
Swelling face
Urticaria (rash of round, red welts on the skin that itch intensely)

30-39:

Dyspnoea (difficult or laboured respiration)
Upper-airway cough syndrome

40-49:

n/a

50-59:

Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Face oedema (swelling of face)
Hepatocellular damage (liver damage)
Inflammation
Leukocytosis (increased white blood cells)
Photosensitivity reaction
Polymorphic light eruption (reaction to sunlight on the skin)
Pruritus (severe itching of the skin)
Rash papular (redness with papule)
Skin eruption

60+:

Anaemia (lack of blood)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Pain in extremity
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Vision blurred
White blood cell count decreased

What are the existing conditions these people have? *

Nasopharyngitis (inflammation of the nasopharynx): 4 people, 22.22%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 22.22%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.11%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 11.11%
Ovarian Cancer (cancer of ovary): 2 people, 11.11%
Neuropathy Peripheral (surface nerve damage): 2 people, 11.11%
Birth Control: 2 people, 11.11%
Insomnia (sleeplessness): 2 people, 11.11%
High Blood Pressure: 2 people, 11.11%
High Blood Cholesterol: 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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