Malic acid and Flonase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Malic acid (alpha hydroxy acids) and Flonase (fluticasone propionate). Common drug interactions include anxiety among females.

The phase IV clinical study analyzes what interactions people have when they take Malic acid and Flonase. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Malic acid?

Malic acid has active ingredients of alpha hydroxy acids. It is often used in fibromyalgia. eHealthMe is studying from 246 Malic acid users. Check the latest studies of Malic acid.

What is Flonase?

Flonase has active ingredients of fluticasone propionate. It is often used in allergies. eHealthMe is studying from 75,441 Flonase users. Check the latest studies of Flonase.



On Jul, 06, 2026

20 people who take Malic acid and Flonase together, and have interactions are studied.

Malic acid and Flonase drug interactions.

What are the common drug interactions of Malic Acid and Flonase, by gender? *:

female:

  1. Anxiety
  2. Pain
  3. Postoperative wound infection
  4. Wheezing (a high-pitched whistling sound made while you breath)
  5. Retinal tear
  6. Stem cell transplant
  7. Deafness unilateral
  8. Hypoacusis (loss of hearing)
  9. Abdominal pain upper
  10. Alopecia (absence of hair from areas of the body)

male:

n/a

What are the common drug interactions of Malic Acid and Flonase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Chronic kidney disease
  2. Hyperkalaemia (damage to or disease of the kidney)
  3. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  4. Nephrogenic anaemia (anaemia due to kidney disease)
  5. Renal failure (kidney dysfunction)
  6. Renal tubular necrosis (death of kidney tubules)

50-59:

  1. Pulmonary embolism (blockage of the main artery of the lung)
  2. Abdominal pain upper
  3. Diarrhoea
  4. Fatigue (feeling of tiredness)
  5. Headache (pain in head)
  6. Nausea (feeling of having an urge to vomit)
  7. Pain

60+:

  1. Application site reaction
  2. Malaise (a feeling of general discomfort or uneasiness)
  3. Nephrolithiasis (calculi in the kidneys)
  4. Skin ulcer

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 75.00%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 20.00%
  3. Drowsiness: 3 people, 15.00%
  4. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 5.00%
  5. Immunodeficiency Common Variable: 1 person, 5.00%
  6. Hair Loss: 1 person, 5.00%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Malic acid and Flonase?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Malic acid and Flonase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Malic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Flonase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Malic acid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Flonase and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on alpha hydroxy acids and fluticasone propionate (the active ingredients of Malic acid and Flonase, respectively), and Malic acid and Flonase (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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