Maxalt-mlt and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Maxalt-mlt (rizatriptan benzoate) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include pain among females and back disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Maxalt-mlt and Flexeril. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Maxalt-mlt?

Maxalt-mlt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 1,534 Maxalt-mlt users. Check the latest studies of Maxalt-mlt.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

On Jul, 10, 2026

47 people who take Maxalt-mlt and Flexeril together, and have interactions are studied.

Maxalt-mlt and Flexeril drug interactions.

What are the common drug interactions of Maxalt-Mlt and Flexeril, by gender? *:

female:

Pain
Insomnia (sleeplessness)
Depression
Nausea (feeling of having an urge to vomit)
Anxiety
Dizziness
Abdominal discomfort
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Pulmonary embolism (blockage of the main artery of the lung)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)

male:

Back disorder
Headache (pain in head)
Renal failure (kidney dysfunction)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Pancreatitis (inflammation of pancreas)
Rash
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Neutropenia (an abnormally low number of neutrophils)

What are the common drug interactions of Maxalt-Mlt and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Circulatory collapse
Dizziness
Fatigue (feeling of tiredness)
Loss of consciousness
Pain in extremity
Pulmonary embolism (blockage of the main artery of the lung)

20-29:

n/a

30-39:

Nausea (feeling of having an urge to vomit)
Pain
Anxiety
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cystitis interstitial (unknown cause characterized by bladder pain)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysuria (painful or difficult urination)
Headache (pain in head)

40-49:

Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Night sweats (sweating in night)
Pelvic discomfort
Pneumonia
Sinusitis (inflammation of sinus)
Snoring
Surgery
Urinary tract infection
Weight decreased

50-59:

Aggression
Arthralgia (joint pain)
Muscular weakness (muscle weakness)
Pain
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Sinusitis (inflammation of sinus)
Suicidal ideation
Abdominal pain
Abdominal pain upper
Agitation (state of anxiety or nervous excitement)

60+:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back disorder
Insomnia (sleeplessness)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Pancreatitis (inflammation of pancreas)
Rash
Cavernous sinus thrombosis (formation of a blood clot in brain)
Sinusitis (inflammation of sinus)
Tooth abscess (pus formation in tooth)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 18 people, 38.30%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 25.53%
Pain: 11 people, 23.40%
Nausea (feeling of having an urge to vomit): 8 people, 17.02%
Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 14.89%
Depression: 6 people, 12.77%
High Blood Cholesterol: 6 people, 12.77%
Stress And Anxiety: 5 people, 10.64%
High Blood Pressure: 4 people, 8.51%
Dry Eyes (lack of adequate tears): 4 people, 8.51%

* Approximation only. Some reports may have incomplete information.

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