Maxzide and Lupron drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Maxzide (hydrochlorothiazide; triamterene) and Lupron (leuprolide acetate). Common drug interactions include vulvovaginal pruritus among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Maxzide and Lupron. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Maxzide?

Maxzide has active ingredients of hydrochlorothiazide; triamterene. It is often used in high blood pressure. eHealthMe is studying from 9,152 Maxzide users. Check the latest studies of Maxzide.

What is Lupron?

Lupron has active ingredients of leuprolide acetate. It is often used in endometriosis. eHealthMe is studying from 42,122 Lupron users. Check the latest studies of Lupron.

On Jul, 27, 2026

47 people who take Maxzide and Lupron together, and have interactions are studied.

What are the common drug interactions of Maxzide and Lupron, by gender? *:

female:

Vulvovaginal pruritus (vulvovaginal severe itching)
Arthralgia (joint pain)
Cataract (clouding of the lens inside the eye)
Cholecystitis (infection of gallbladder)
Drug effect decreased
Dysarthria (speech disorder)
Headache (pain in head)
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Menstrual disorder (disease of menstrual cycle)

male:

Constipation
Death
Arrhythmia (irregular heartbeat)
Dental caries
Disability
Gingival erythema (redness of gums)
Gingival hypertrophy (overgrowth of gums)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Injury
Pain in jaw

What are the common drug interactions of Maxzide and Lupron, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Vulvovaginal pruritus (vulvovaginal severe itching)
Arthralgia (joint pain)
Cataract (clouding of the lens inside the eye)
Drug effect decreased
Headache (pain in head)
Menstrual disorder (disease of menstrual cycle)
Pain
Peripheral swelling
Swelling face
Vaginal haemorrhage (vaginal bleeding)

40-49:

Nausea (feeling of having an urge to vomit)
Vaginal haemorrhage (vaginal bleeding)
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Constipation
Intestinal obstruction

50-59:

Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
Dysphagia (a condition in which swallowing is difficult or painful)
Tongue oedema (swelling of tongue)
Dysarthria (speech disorder)
Speech disorder

60+:

Constipation
Death
Arrhythmia (irregular heartbeat)
Dental caries
Disability
Gingival erythema (redness of gums)
Gingival hypertrophy (overgrowth of gums)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Injury
Pain in jaw

What are the existing conditions these people have? *

Prostate Cancer: 15 people, 31.91%
Pain: 10 people, 21.28%

* Approximation only. Some reports may have incomplete information.

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