Mekinist and Pradaxa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mekinist (trametinib dimethyl sulfoxide) and Pradaxa (dabigatran etexilate mesylate). Common drug interactions include asthenia among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Mekinist and Pradaxa. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Mekinist?

Mekinist has active ingredients of trametinib dimethyl sulfoxide. eHealthMe is studying from 17,350 Mekinist users. Check the latest studies of Mekinist.

What is Pradaxa?

Pradaxa has active ingredients of dabigatran etexilate mesylate. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 86,906 Pradaxa users. Check the latest studies of Pradaxa.

On Jul, 20, 2026

11 people who take Mekinist and Pradaxa together, and have interactions are studied.

What are the common drug interactions of Mekinist and Pradaxa, by gender? *:

female:

Asthenia (weakness)
Chills (felling of cold)
Dizziness
Dry mouth
Faeces discoloured
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Night sweats (sweating in night)

male:

Asthenia (weakness)
Disease progression
Pneumonia
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Pyrexia (fever)
Renal impairment (severely reduced kidney function)
Respiratory rate decreased (less breathing rate/min)
Adverse reaction
Blood creatine phosphokinase increased
Confusional state

What are the common drug interactions of Mekinist and Pradaxa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Disease progression
Malignant melanoma (skin cancer rises from melancytes)

40-49:

n/a

50-59:

n/a

60+:

Asthenia (weakness)
Hypotension (abnormally low blood pressure)
Autoimmune pancreatitis (autoimmune pancreatitis (aip) is an increasingly recognized type of chronic pancreatitis)
Cardiac failure congestive
Death
Diarrhoea
Dyspnoea (difficult or laboured respiration)
General physical health deterioration (weak health status)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Myxoedema coma (coma with long untreated hypothyroidism)

What are the existing conditions these people have? *

Malignant Melanoma (skin cancer rises from melancytes): 5 people, 45.45%
Pulmonary Embolism (blockage of the main artery of the lung): 2 people, 18.18%
Lung Neoplasm Malignant (cancer tumour of lung): 2 people, 18.18%
Insomnia (sleeplessness): 2 people, 18.18%
High Blood Pressure: 2 people, 18.18%
Neuropathy Peripheral (surface nerve damage): 1 person, 9.09%
Multiple Myeloma (cancer of the plasma cells): 1 person, 9.09%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 1 person, 9.09%
Hyperglycemia (high blood sugar): 1 person, 9.09%
Herpes Simplex (herpes simplex is a common viral infection): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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