Mellaril and Fentanyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mellaril (thioridazine hydrochloride) and Fentanyl (fentanyl citrate). Common drug interactions include drug hypersensitivity among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Mellaril and Fentanyl. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Mellaril?

Mellaril has active ingredients of thioridazine hydrochloride. eHealthMe is studying from 1,516 Mellaril users. Check the latest studies of Mellaril.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.



On Jul, 12, 2026

12 people who take Mellaril and Fentanyl together, and have interactions are studied.

Mellaril and Fentanyl drug interactions.

What are the common drug interactions of Mellaril and Fentanyl, by gender? *:

female:

  1. Drug hypersensitivity
  2. Anaphylactic reaction (serious allergic reaction)
  3. Blood creatinine decreased
  4. Blood urea decreased
  5. Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
  6. Flushing (the warm, red condition of human skin)
  7. Hypotension (abnormally low blood pressure)
  8. Oliguria (not enough urine)
  9. Rash generalised (rash on most of body parts)
  10. Tachycardia (a heart rate that exceeds the range of 100 beats/min)

male:

  1. Anxiety
  2. Chest pain
  3. Arthralgia (joint pain)
  4. Blood oestrogen increased
  5. Bone disorder
  6. Constipation
  7. Death
  8. Decreased interest
  9. Depression
  10. Emotional distress

What are the common drug interactions of Mellaril and Fentanyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Anaphylactic reaction (serious allergic reaction)
  2. Blood creatinine decreased
  3. Blood urea decreased
  4. Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
  5. Flushing (the warm, red condition of human skin)
  6. Hypotension (abnormally low blood pressure)
  7. Oliguria (not enough urine)
  8. Rash generalised (rash on most of body parts)
  9. Tachycardia (a heart rate that exceeds the range of 100 beats/min)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Anxiety
  2. Emotional distress
  3. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  4. General physical health deterioration (weak health status)
  5. Gingival disorder (gum disease)
  6. Hallucination, visual (seeing things that aren't there)
  7. Hypoaesthesia (reduced sense of touch or sensation)
  8. Impaired healing
  9. Jaw disorder (jaw disease)
  10. Metastases to bone (cancer spreads to bone)

60+:

  1. Drug hypersensitivity

What are the existing conditions these people have? *

  1. Stress And Anxiety: 6 people, 50.00%
  2. Panic Disorder: 6 people, 50.00%
  3. Gastric Ulcer (stomach ulcer): 6 people, 50.00%
  4. Nausea (feeling of having an urge to vomit): 5 people, 41.67%
  5. Prostate Cancer: 3 people, 25.00%
  6. Metastases To Bone (cancer spreads to bone): 3 people, 25.00%
  7. Insomnia (sleeplessness): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Mellaril and Fentanyl?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Mellaril and Fentanyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Mellaril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Fentanyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Mellaril and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Fentanyl and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on thioridazine hydrochloride and fentanyl citrate (the active ingredients of Mellaril and Fentanyl, respectively), and Mellaril and Fentanyl (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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