Melphalan and Aleve drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melphalan (melphalan) and Aleve (naproxen sodium). Common drug interactions include haematuria among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Melphalan and Aleve. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Melphalan?

Melphalan has active ingredients of melphalan. eHealthMe is studying from 20,052 Melphalan users. Check the latest studies of Melphalan.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

On Jul, 13, 2026

11 people who take Melphalan and Aleve together, and have interactions are studied.

What are the common drug interactions of Melphalan and Aleve, by gender? *:

female:

Haematuria (presence of blood in urine)
Haemophilus infection (bacterial infection by haemophilus influenzae)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Haemorrhage (bleeding)
Hair follicle tumour benign
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hyperhidrosis (abnormally increased sweating)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypertension (high blood pressure)

male:

Dizziness
Monoclonal immunoglobulin present
Decreased appetite
Diarrhoea
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)
Liver disorder (liver diseases)
Mucosal inflammation (infection of mucous membrane)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Melphalan and Aleve, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Glomerular filtration rate decreased
Haematoma (collection of blood outside the blood vessels)
Haematuria (presence of blood in urine)
Haemophilus infection (bacterial infection by haemophilus influenzae)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Haemorrhage (bleeding)
Hair follicle tumour benign
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hyperhidrosis (abnormally increased sweating)

50-59:

Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Decreased appetite
Diarrhoea
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Febrile neutropenia (fever with reduced white blood cells)
Mucosal inflammation (infection of mucous membrane)
Nausea (feeling of having an urge to vomit)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Platelet count decreased
Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

Dizziness
Monoclonal immunoglobulin present
Pancreatic carcinoma metastatic (pancreatic cancer- metastatic)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Plasma cell myeloma (cancer that begins in plasma cells)
Pneumonia
Pruritus (severe itching of the skin)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Thyroid cancer metastatic (thyroid cancer spreads to other part)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 8 people, 72.73%
Nausea (feeling of having an urge to vomit): 5 people, 45.45%
Nausea And Vomiting: 4 people, 36.36%
Urinary Tract Infection: 3 people, 27.27%
High Blood Pressure: 3 people, 27.27%
Swelling: 2 people, 18.18%
Stress And Anxiety: 1 person, 9.09%
Sinus Congestion (blockage of sinus): 1 person, 9.09%
Muscle Spasms (muscle contraction): 1 person, 9.09%
Irritable Bowel Syndrome: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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