Mesalamine and Vesicare drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mesalamine (mesalamine) and Vesicare (solifenacin succinate). Common drug interactions include restless legs syndrome among females and chronic obstructive pulmonary disease among males.

The phase IV clinical study analyzes what interactions people have when they take Mesalamine and Vesicare. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Mesalamine?

Mesalamine has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 28,053 Mesalamine users. Check the latest studies of Mesalamine.

What is Vesicare?

Vesicare has active ingredients of solifenacin succinate. It is often used in urge incontinence. eHealthMe is studying from 30,655 Vesicare users. Check the latest studies of Vesicare.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

14 people who take Mesalamine and Vesicare together, and have interactions are studied.

Mesalamine and Vesicare drug interactions.

What are the common drug interactions of Mesalamine and Vesicare, by gender? *:

female:

Restless legs syndrome (a powerful urge to move your legs)
Circulatory collapse
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Disturbance in attention
Dry eye (lack of adequate tears)
Dry mouth
Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Cyst (a closed sac)

male:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dyspnoea (difficult or laboured respiration)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Gait disturbance
Ill-defined disorder

What are the common drug interactions of Mesalamine and Vesicare, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Back pain
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Muscle spasms (muscle contraction)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nausea (feeling of having an urge to vomit)
Neck pain
Pain in extremity
Throat tightness

40-49:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Blood pressure increased
Constipation
Headache (pain in head)
Heart rate decreased
Heart rate increased
Influenza like illness
Kidney infection
Lethargy (tiredness)

50-59:

Pain
Fatigue (feeling of tiredness)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Restless legs syndrome (a powerful urge to move your legs)
Arthralgia (joint pain)
Cyst (a closed sac)
Dizziness
Cystitis interstitial (unknown cause characterized by bladder pain)
Intervertebral disc degeneration (spinal disc degeneration)

60+:

Circulatory collapse
Dehydration (dryness resulting from the removal of water)
Chills (felling of cold)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dyspnoea (difficult or laboured respiration)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Gait disturbance
Ill-defined disorder
Incisional hernia (hernia caused by an incompletely-healed surgical wound)
Infection

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 28.57%
Cystitis Interstitial (unknown cause characterized by bladder pain): 4 people, 28.57%
High Blood Pressure: 2 people, 14.29%
Asthma: 2 people, 14.29%
Bladder Disorder: 2 people, 14.29%
Bladder Pain: 2 people, 14.29%
Bladder Spasm: 2 people, 14.29%
Blood Glucose Increased: 2 people, 14.29%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 14.29%
Depression: 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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